“Sphingomyelin synthase”的意思、由来-开放百科全书

词条

Sphingomyelin synthase

释义

References

{{enzyme
| Name = sphingomyelin synthase
| EC_number = 2.7.8.27
| CAS_number =
| IUBMB_EC_number = 2/7/8/27
| GO_code = 0033188
| image =
| width =
| caption =
}}

In enzymology, a sphingomyelin synthase ({{EC number|2.7.8.27}}) is an enzyme that catalyzes the chemical reaction

a ceramide + a phosphatidylcholine a sphingomyelin + a 1,2-diacyl-sn-glycerol

Thus, the two substrates of this enzyme are ceramide and phosphatidylcholine, whereas its two products are sphingomyelin and 1,2-diacyl-sn-glycerol.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is ceramide:phosphatidylcholine cholinephosphotransferase. Other names in common use include SM synthase, SMS1, and SMS2.

References

{{cite journal |vauthors=Ullman MD, Radin NS | year = 1974 | title = The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver | journal = J. Biol. Chem. | volume = 249 | pages = 1506–12 | pmid = 4817756 | issue = 5 }}
{{cite journal |vauthors=Voelker DR, Kennedy EP | year = 1982 | title = Cellular and enzymic synthesis of sphingomyelin | journal = Biochemistry | volume = 21 | pages = 2753–9 | pmid = 7093220 | doi = 10.1021/bi00540a027 | issue = 11 }}
{{cite journal |vauthors=Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC | year = 2004 | title = Identification of a family of animal sphingomyelin synthases | journal = EMBO J. | volume = 23 | pages = 33–44 | pmid = 14685263 | doi = 10.1038/sj.emboj.7600034 | issue = 1 | pmc = 1271672 }}
{{cite journal |vauthors=Tafesse FG, Ternes P, Holthuis JC | year = 2006 | title = The multigenic sphingomyelin synthase family | journal = J. Biol. Chem. | volume = 281 | pages = 29421–5 | pmid = 16905542 | doi = 10.1074/jbc.R600021200 | issue = 40 }}
{{cite journal |vauthors=Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T | year = 2004 | title = Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells | journal = J. Biol. Chem. | volume = 279 | pages = 18688–93 | pmid = 14976195 | doi = 10.1074/jbc.M401205200 | issue = 18 }}

2 : EC 2.7.8|Enzymes of unknown structure

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