| 释义 |
- See also
- References
- Further reading
{{Infobox_gene}}Pancreatic secretory trypsin inhibitor (PSTI) also known as serine protease inhibitor Kazal-type 1 (SPINK1) or tumor-associated trypsin inhibitor (TATI) is a protein that in humans is encoded by the SPINK1 gene.[1]Mutations in SPINK1 has been associated with hereditary pancreatitis and tropical pancreatitis. Trypsinogen is normally created and stored an inactive zymogen of trypsin in the pancreas, but occasionally will autoactivate itself. PSTI serves to cleave prematurely activated trypsin to prevent the enzyme from causing cellular damage to the organ. Without the function of PSTI, the pancreas is subject to repeated episodes of damage.[2] It has also been associated with prostate cancer.[3] See also - Kazal-type serine protease inhibitor domain
- Pancreatitis
References 1. ^{{cite web | title = Entrez Gene: SPINK1 serine peptidase inhibitor, Kazal type 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6690| accessdate = }}
2. ^{{cite web|last1=Schneider|first1=A.|title=SPINK1 - serine peptidase inhibitor, Kazal type 1|url=https://www.wikigenes.org/e/gene/e/6690.html|website=Wikigenes}}
3. ^{{cite journal | vauthors = Tomlins SA, Rhodes DR, Yu J, Varambally S, Mehra R, Perner S, Demichelis F, Helgeson BE, Laxman B, Morris DS, Cao Q, Cao X, Andrén O, Fall K, Johnson L, Wei JT, Shah RB, Al-Ahmadie H, Eastham JA, Eggener SE, Fine SW, Hotakainen K, Stenman UH, Tsodikov A, Gerald WL, Lilja H, Reuter VE, Kantoff PW, Scardino PT, Rubin MA, Bjartell AS, Chinnaiyan AM | title = The role of SPINK1 in ETS rearrangement-negative prostate cancers | journal = Cancer Cell | volume = 13 | issue = 6 | pages = 519–28 | date = Jun 2008 | pmid = 18538735 | pmc = 2732022 | doi = 10.1016/j.ccr.2008.04.016 | url = http://linkinghub.elsevier.com/retrieve/pii/S1535-6108(08)00152-9 | displayauthors = 6 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Marchbank T, Freeman TC, Playford RJ | title = Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair | journal = Digestion | volume = 59 | issue = 3 | pages = 167–74 | year = 1998 | pmid = 9643675 | doi = 10.1159/000007485 }}
- {{cite journal | vauthors = Pfützer RH, Whitcomb DC | title = SPINK1 mutations are associated with multiple phenotypes | journal = Pancreatology | volume = 1 | issue = 5 | pages = 457–60 | year = 2002 | pmid = 12120224 | doi = 10.1159/000055847 }}
- {{cite journal | vauthors = Schneider A | title = Serine protease inhibitor kazal type 1 mutations and pancreatitis | journal = Clinics in Laboratory Medicine | volume = 25 | issue = 1 | pages = 61–78 | date = Mar 2005 | pmid = 15749232 | doi = 10.1016/j.cll.2004.12.005 }}
- {{cite journal | vauthors = Cohn JA, Mitchell RM, Jowell PS | title = The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis | journal = Clinics in Laboratory Medicine | volume = 25 | issue = 1 | pages = 79–100 | date = Mar 2005 | pmid = 15749233 | doi = 10.1016/j.cll.2004.12.007 }}
- {{cite journal | vauthors = Kandula L, Whitcomb DC, Lowe ME | title = Genetic issues in pediatric pancreatitis | journal = Current Gastroenterology Reports | volume = 8 | issue = 3 | pages = 248–53 | date = Jun 2006 | pmid = 16764792 | doi = 10.1007/s11894-006-0083-8 }}
- {{cite journal | vauthors = Bartelt DC, Shapanka R, Greene LJ | title = The primary structure of the human pancreatic secretory trypsin inhibitor. Amino acid sequence of the reduced S-aminoethylated protein | journal = Archives of Biochemistry and Biophysics | volume = 179 | issue = 1 | pages = 189–99 | date = Feb 1977 | pmid = 843082 | doi = 10.1016/0003-9861(77)90103-5 }}
- {{cite journal | vauthors = Hecht HJ, Szardenings M, Collins J, Schomburg D | title = Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type) | journal = Journal of Molecular Biology | volume = 225 | issue = 4 | pages = 1095–103 | date = Jun 1992 | pmid = 1613792 | doi = 10.1016/0022-2836(92)90107-U }}
- {{cite journal | vauthors = Hecht HJ, Szardenings M, Collins J, Schomburg D | title = Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type) | journal = Journal of Molecular Biology | volume = 220 | issue = 3 | pages = 711–22 | date = Aug 1991 | pmid = 1870127 | doi = 10.1016/0022-2836(91)90112-J }}
- {{cite journal | vauthors = Freeman TC, Davies R, Calam J | title = Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors | journal = Clinica Chimica Acta; International Journal of Clinical Chemistry | volume = 195 | issue = 1-2 | pages = 27–39 | date = Dec 1990 | pmid = 2093478 | doi = 10.1016/0009-8981(90)90191-T }}
- {{cite journal | vauthors = Kido H, Yokogoshi Y, Katunuma N | title = A low-molecular-mass Kazal-type protease inhibitor isolated from rat hepatocytes is identical to rat pancreatic secretory trypsin inhibitor II. Purification and amino acid sequence | journal = European Journal of Biochemistry / FEBS | volume = 188 | issue = 3 | pages = 501–6 | date = Mar 1990 | pmid = 2110056 | doi = 10.1111/j.1432-1033.1990.tb15428.x }}
- {{cite journal | vauthors = Tomita N, Horii A, Yamamoto T, Ogawa M, Mori T, Matsubara K | title = Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissues | journal = FEBS Letters | volume = 225 | issue = 1-2 | pages = 113–9 | date = Dec 1987 | pmid = 2961612 | doi = 10.1016/0014-5793(87)81141-9 }}
- {{cite journal | vauthors = Horii A, Kobayashi T, Tomita N, Yamamoto T, Fukushige S, Murotsu T, Ogawa M, Mori T, Matsubara K | title = Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene | journal = Biochemical and Biophysical Research Communications | volume = 149 | issue = 2 | pages = 635–41 | date = Dec 1987 | pmid = 3501289 | doi = 10.1016/0006-291X(87)90415-3 }}
- {{cite journal | vauthors = Yamamoto T, Nakamura Y, Nishide J, Emi M, Ogawa M, Mori T, Matsubara K | title = Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA | journal = Biochemical and Biophysical Research Communications | volume = 132 | issue = 2 | pages = 605–12 | date = Oct 1985 | pmid = 3877508 | doi = 10.1016/0006-291X(85)91176-3 }}
- {{cite journal | vauthors = Huhtala ML, Pesonen K, Kalkkinen N, Stenman UH | title = Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer | journal = The Journal of Biological Chemistry | volume = 257 | issue = 22 | pages = 13713–6 | date = Nov 1982 | pmid = 7142173 | doi = }}
- {{cite journal | vauthors = Klaus W, Schomburg D | title = Solution structure of a variant of human pancreatic secretory trypsin inhibitor determined by nuclear magnetic resonance spectroscopy | journal = Journal of Molecular Biology | volume = 229 | issue = 3 | pages = 695–706 | date = Feb 1993 | pmid = 8433367 | doi = 10.1006/jmbi.1993.1073 }}
- {{cite journal | vauthors = Chen JM, Mercier B, Audrezet MP, Ferec C | title = Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis | journal = Journal of Medical Genetics | volume = 37 | issue = 1 | pages = 67–9 | date = Jan 2000 | pmid = 10691414 | pmc = 1734438 | doi = 10.1136/jmg.37.1.67 }}
- {{cite journal | vauthors = Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, Landt O, Becker M | title = Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis | journal = Nature Genetics | volume = 25 | issue = 2 | pages = 213–6 | date = Jun 2000 | pmid = 10835640 | doi = 10.1038/76088 }}
- {{cite journal | vauthors = Pfützer RH, Barmada MM, Brunskill AP, Finch R, Hart PS, Neoptolemos J, Furey WF, Whitcomb DC | title = SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis | journal = Gastroenterology | volume = 119 | issue = 3 | pages = 615–23 | date = Sep 2000 | pmid = 10982753 | doi = 10.1053/gast.2000.18017 }}
- {{cite journal | vauthors = Kaneko K, Nagasaki Y, Furukawa T, Mizutamari H, Sato A, Masamune A, Shimosegawa T, Horii A | title = Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis | journal = Journal of Human Genetics | volume = 46 | issue = 5 | pages = 293–7 | year = 2001 | pmid = 11355022 | doi = 10.1007/s100380170082 }}
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