“SPOP”的意思、由来-开放百科全书

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.^[3]

Clinical relevance

Mutations in SPOP lead to a type of prostate tumor thought to be involved in about 15% of all prostate cancers.^[4]^[5]

References

1. ^{{cite journal | vauthors = Nagai Y, Kojima T, Muro Y, Hachiya T, Nishizawa Y, Wakabayashi T, Hagiwara M | title = Identification of a novel nuclear speckle-type protein, SPOP | journal = FEBS Letters | volume = 418 | issue = 1-2 | pages = 23–6 | date = Nov 1997 | pmid = 9414087 | pmc = | doi = 10.1016/S0014-5793(97)01340-9 }}
2. ^{{cite journal | vauthors = Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC | title = A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 24242–52 | date = Jun 2001 | pmid = 11279055 | doi = 10.1074/jbc.M100354200 }}
3. ^¹{{cite web | title = Entrez Gene: SPOP speckle-type POZ protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8405| accessdate = }}
4. ^{{cite news |title=Scientists find new type of prostate cancer - discovery may lead to tailored treatments |author=Heidi Evans |url=http://www.nydailynews.com/life-style/health/scientists-find-type-prostate-cancer-discovery-lead-tailored-treatments-article-1.1081547 |newspaper=New York Daily News |date=20 May 2012 |accessdate=20 May 2012}}
5. ^{{cite journal | vauthors = Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA | title = Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer | journal = Nature Genetics | volume = 44 | issue = 6 | pages = 685–9 | date = Jun 2012 | pmid = 22610119 | pmc = 3673022 | doi = 10.1038/ng.2279 }}

Further reading

{{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}

{{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}

{{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}

{{cite journal | vauthors = Wu J, Song Y, Bakker AB, Bauer S, Spies T, Lanier LL, Phillips JH | title = An activating immunoreceptor complex formed by NKG2D and DAP10 | journal = Science | volume = 285 | issue = 5428 | pages = 730–2 | date = Jul 1999 | pmid = 10426994 | doi = 10.1126/science.285.5428.730 }}

{{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}

{{cite journal | vauthors = Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC | title = A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 24242–52 | date = Jun 2001 | pmid = 11279055 | doi = 10.1074/jbc.M100354200 }}

{{cite journal | vauthors = Takahashi I, Kameoka Y, Hashimoto K | title = MacroH2A1.2 binds the nuclear protein Spop | journal = Biochimica et Biophysica Acta | volume = 1591 | issue = 1-3 | pages = 63–8 | date = Aug 2002 | pmid = 12183056 | doi = 10.1016/S0167-4889(02)00249-5 }}

{{cite journal | vauthors = Gilfillan S, Ho EL, Cella M, Yokoyama WM, Colonna M | title = NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation | journal = Nature Immunology | volume = 3 | issue = 12 | pages = 1150–5 | date = Dec 2002 | pmid = 12426564 | doi = 10.1038/ni857 }}

{{cite journal | vauthors = Diefenbach A, Tomasello E, Lucas M, Jamieson AM, Hsia JK, Vivier E, Raulet DH | title = Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D | journal = Nature Immunology | volume = 3 | issue = 12 | pages = 1142–9 | date = Dec 2002 | pmid = 12426565 | doi = 10.1038/ni858 }}

{{cite journal | vauthors = Billadeau DD, Upshaw JL, Schoon RA, Dick CJ, Leibson PJ | title = NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway | journal = Nature Immunology | volume = 4 | issue = 6 | pages = 557–64 | date = Jun 2003 | pmid = 12740575 | doi = 10.1038/ni929 }}

{{cite journal | vauthors = Liu A, Desai BM, Stoffers DA | title = Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity | journal = Molecular and Cellular Biology | volume = 24 | issue = 10 | pages = 4372–83 | date = May 2004 | pmid = 15121856 | pmc = 400448 | doi = 10.1128/MCB.24.10.4372-4383.2004 }}

{{cite journal | vauthors = La M, Kim K, Park J, Won J, Lee JH, Fu YM, Meadows GG, Joe CO | title = Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP | journal = Biochemical and Biophysical Research Communications | volume = 320 | issue = 3 | pages = 760–5 | date = Jul 2004 | pmid = 15240113 | doi = 10.1016/j.bbrc.2004.06.022 }}

{{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}

{{cite journal | vauthors = Hernández-Muñoz I, Lund AH, van der Stoop P, Boutsma E, Muijrers I, Verhoeven E, Nusinow DA, Panning B, Marahrens Y, van Lohuizen M | title = Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 21 | pages = 7635–40 | date = May 2005 | pmid = 15897469 | pmc = 1140410 | doi = 10.1073/pnas.0408918102 }}

{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

{{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}