| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Signal peptide peptidase-like 2A, also known as SPPL2A, is a human gene.[1] Function This gene is a member of the signal peptide peptidase-like protease (SPPL) family and encodes a lysosomal/late endosomal membrane protein[1] with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells.[2][3] A pseudogene of this gene also lies on chromosome 15.[4] References1. ^{{cite journal | vauthors = Behnke J, Schneppenheim J, Koch-Nolte F, Haag F, Saftig P, Schröder B | title = Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail | journal = FEBS Letters | volume = 585 | issue = 19 | pages = 2951–7 | year = 2011 | pmid = 21896273 | doi = 10.1016/j.febslet.2011.08.043 }}
2. ^{{cite journal |vauthors=Friedmann E, Hauben E, Maylandt K, etal |title=SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production |journal=Nat. Cell Biol. |volume=8 |issue=8 |pages=843–8 |year=2006 |pmid=16829952 |doi=10.1038/ncb1440}}
3. ^{{cite journal |vauthors=Fluhrer R, Grammer G, Israel L, etal |title=A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b |journal=Nat. Cell Biol. |volume=8 |issue=8 |pages=894–6 |year=2006 |pmid=16829951 |doi=10.1038/ncb1450}}
4. ^1 {{cite web | title = Entrez Gene: SPPL2A signal peptide peptidase-like 2A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84888| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Weihofen A, Binns K, Lemberg MK, etal |title=Identification of signal peptide peptidase, a presenilin-type aspartic protease. |journal=Science |volume=296 |issue= 5576 |pages= 2215–8 |year= 2002 |pmid= 12077416 |doi= 10.1126/science.1070925 }}
- {{cite journal | vauthors=Grigorenko AP, Moliaka YK, Korovaitseva GI, Rogaev EI |title=Novel class of polytopic proteins with domains associated with putative protease activity. |journal=Biochemistry Mosc. |volume=67 |issue= 7 |pages= 826–35 |year= 2002 |pmid= 12139484 |doi=10.1023/A:1016365227942 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Granneman S, Gallagher JE, Vogelzangs J, etal |title=The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60–80S ribonucleoprotein complexes |journal=Nucleic Acids Res. |volume=31 |issue= 7 |pages= 1877–87 |year= 2003 |pmid= 12655004 |doi=10.1093/nar/gkg300 | pmc=152815 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Friedmann E, Lemberg MK, Weihofen A, etal |title=Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 50790–8 |year= 2005 |pmid= 15385547 |doi= 10.1074/jbc.M407898200 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
- {{cite journal |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Kirkin V, Cahuzac N, Guardiola-Serrano F, etal |title=The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells |journal=Cell Death Differ. |volume=14 |issue= 9 |pages= 1678–87 |year= 2007 |pmid= 17557115 |doi= 10.1038/sj.cdd.4402175 }}
{{refend}}{{gene-15-stub}} |