请输入您要查询的百科知识：

　

词条 SPTAN1
释义

  1. Structure

  2. Function

  3. Clinical significance

  4. Interactions

  5. See also

  6. References

  7. Further reading

{{Infobox_gene}}

Alpha II-spectrin, also known as Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene.[1][2][3] Alpha II-spectrin is expressed in a variety of tissues, and is highly expressed in cardiac muscle at Z-disc structures, costameres and at the sarcolemma membrane. Mutations in alpha II-spectrin have been associated with early infantile epileptic encephalopathy-5, and alpha II-spectrin may be a valuable biomarker for Guillain–Barré syndrome and infantile congenital heart disease.

Structure

Alternate splicing of alpha II-spectrin has been documented and results in multiple transcript variants; specifically, cardiomyocytes have four identified alpha II-spectrin splice variants.[4][5] As opposed to alpha I-spectrin that is principally found in erythrocytes,[6] alpha II-spectrin is expressed in most tissues. In cardiac tissue, alpha II-spectrin is found in myocytes at Z-discs, costameres, and the sarcolemma membrane,[7][8][9] and in cardiac fibroblasts along the surface of the cytoskeletal network.[10] Alpha II-spectrin most commonly exists in a heterodimer with alpha II and beta II spectrin subunits; and dimers typically self-associate and heterotetramerize.[1][11][12]

Function

The spectrins are a family of widely distributed cytoskeletal proteins which are involved in actin crosslinking, cell adhesion, intercellular communication and cell cycle regulation.[13][14][15] Though a role in cardiac muscle is not well understood, it is likely that alpha II-spectrin is involved in organizing sub-sarcolemmal domains and stabilizing sarcolemmal membranes against the stresses associated with continuous cardiac contraction.[12] Functional diversity of alpha II-spectrin is manifest through its four splice variants. First, a cardiac-specific, 21 amino acid sequence insert in the 21st spectrin repeat, termed alpha II-cardi+, was identified as an insert that modulates affinity of alpha II-spectrin for binding beta-spectrins and regulates myocyte growth and differentiation.[4] Secondly, another insert of 20 amino acids in the 10th spectrin repeat, termed SH3i+, contains protein kinase A and protein kinase C phosphorylation sites and modulates Ca2+-dependent cleavage of spectrin and protein-protein interaction properties.[16] Thirdly, an insert of five amino acids in the fifteenth spectrin motif bears a highly antigenic epitope resembling an ankyrin-like p53 binding protein binding site.[4][17] Fourthly, a six amino acid insert in the twenty-first spectrin motif with unknown function has been reported.[7][18]

Alpha II-spectrin gene expression has been shown to be upregulated in cardiac fibroblasts in response to Angiotensin II-induced cardiac remodeling.[19]

In animal models of disease and injury, alpha II-spectrin has been implicated in diverse functions. In a canine model of hypothermic circulatory arrest, alpha II-spectrin breakdown products have shown to be relevant markers of neurologic injury post-cardiac surgery.[20]

Clinical significance

Mutations in SPTAN1 are the cause of early infantile epileptic encephalopathy-5.[21]

Alpha II-spectrin has shown promising utility as a biomarker for brain necrosis and apoptosis in infants with congenital heart disease; breakdown products of alpha II-spectrin have been detected in the serum of neonates in the perioperative period and following open-heart surgery.[22] Elevated protein expression of alpha II-spectrin has been detected in cerebrospinal fluid in patients with Guillain–Barré syndrome.[23]

Interactions

SPTAN1 has been shown to interact with:

  • Abl gene,[24]
  • FANCA,[30][31][25]
  • Fanconi anemia, complementation group C,[26][27]
  • GRIA2,[28]
  • Plectin,[36][29]
  • SHANK1,[30] and
  • Vimentin.[31]

See also

  • Sjögren's syndrome

References

1. ^1 {{cite journal | vauthors = Leto TL, Fortugno-Erikson D, Barton D, Yang-Feng TL, Francke U, Harris AS, Morrow JS, Marchesi VT, Benz EJ | title = Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species | journal = Mol Cell Biol | volume = 8 | issue = 1 | pages = 1–9 | date = February 1988 | pmid = 3336352 | pmc = 363070 | doi = 10.1128/MCB.8.1.1}}
2. ^{{cite journal | title = Entrez Gene: SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)| journal = Molecular and Cellular Biology | volume = 8 | issue = 1 | pages = 1–9 | doi = 10.1128/MCB.8.1.1 | pmid = 3336352 | pmc = 363070 | year = 1988 | last1 = Leto | first1 = T. L. | last2 = Fortugno-Erikson | first2 = D. | last3 = Barton | first3 = D. | last4 = Yang-Feng | first4 = T. L. | last5 = Francke | first5 = U. | last6 = Harris | first6 = A. S. | last7 = Morrow | first7 = J. S. | last8 = Marchesi | first8 = V. T. | last9 = Benz | first9 = E. J. }}
3. ^{{cite journal | vauthors = McMahon AP, Giebelhaus DH, Champion JE, Bailes JA, Lacey S, Carritt B, Henchman SK, Moon RT | title = cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin | journal = Differentiation | volume = 34 | issue = 1 | pages = 68–78 | year = 1987 | pmid = 3038643 | doi = 10.1111/j.1432-0436.1987.tb00052.x | url = }}
4. ^1 2 {{cite journal | vauthors = Zhang Y, Resneck WG, Lee PC, Randall WR, Bloch RJ, Ursitti JA | title = Characterization and expression of a heart-selective alternatively spliced variant of alpha II-spectrin, cardi+, during development in the rat | journal = Journal of Molecular and Cellular Cardiology | volume = 48 | issue = 6 | pages = 1050–9 | date = Jun 2010 | pmid = 20114050 | doi = 10.1016/j.yjmcc.2010.01.001 | pmc=3537504}}
5. ^{{cite journal | vauthors = Cianci CD, Zhang Z, Pradhan D, Morrow JS | title = Brain and muscle express a unique alternative transcript of alphaII spectrin | journal = Biochemistry | volume = 38 | issue = 48 | pages = 15721–30 | date = Nov 1999 | pmid = 10625438 | doi=10.1021/bi991458k}}
6. ^{{cite journal | vauthors = Ursitti JA, Kotula L, DeSilva TM, Curtis PJ, Speicher DW | title = Mapping the human erythrocyte beta-spectrin dimer initiation site using recombinant peptides and correlation of its phasing with the alpha-actinin dimer site | journal = The Journal of Biological Chemistry | volume = 271 | issue = 12 | pages = 6636–44 | date = Mar 1996 | pmid = 8636080 | doi = 10.1074/jbc.271.12.6636 }}
7. ^1 {{cite journal | vauthors = Du A, Sanger JM, Sanger JW | title = Cardiac myofibrillogenesis inside intact embryonic hearts | journal = Developmental Biology | volume = 318 | issue = 2 | pages = 236–46 | date = Jun 2008 | pmid = 18455713 | doi = 10.1016/j.ydbio.2008.03.011 | pmc=2496890}}
8. ^{{cite journal | vauthors = Bennett PM, Maggs AM, Baines AJ, Pinder JC | title = The transitional junction: a new functional subcellular domain at the intercalated disc | journal = Molecular Biology of the Cell | volume = 17 | issue = 4 | pages = 2091–100 | date = Apr 2006 | pmid = 16481394 | doi = 10.1091/mbc.E05-12-1109 | pmc=1415289}}
9. ^{{cite journal | vauthors = Bennett PM, Baines AJ, Lecomte MC, Maggs AM, Pinder JC | title = Not just a plasma membrane protein: in cardiac muscle cells alpha-II spectrin also shows a close association with myofibrils | journal = Journal of Muscle Research and Cell Motility | volume = 25 | issue = 2 | pages = 119–26 | date = 2004 | pmid = 15360127 | doi=10.1023/b:jure.0000035892.77399.51}}
10. ^{{cite journal | vauthors = Sormunen R | title = Alpha-spectrin in detergent-extracted whole-mount cytoskeletons of chicken embryo heart fibroblasts | journal = The Histochemical Journal | volume = 25 | issue = 9 | pages = 678–86 | date = Sep 1993 | pmid = 8226104 | doi=10.1007/bf00157882}}
11. ^{{cite journal | vauthors = Bignone PA, Baines AJ | title = Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site | journal = The Biochemical Journal | volume = 374 | issue = Pt 3 | pages = 613–24 | date = Sep 2003 | pmid = 12820899 | doi = 10.1042/BJ20030507 | pmc=1223645}}
12. ^1 {{cite journal | vauthors = Baines AJ, Pinder JC | title = The spectrin-associated cytoskeleton in mammalian heart | journal = Frontiers in Bioscience | volume = 10 | issue = 1–3 | pages = 3020–33 | date = 1 September 2005 | pmid = 15970557 | doi=10.2741/1759}}
13. ^{{cite journal | vauthors = Ursitti JA, Petrich BG, Lee PC, Resneck WG, Ye X, Yang J, Randall WR, Bloch RJ, Wang Y | title = Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase | journal = Journal of Molecular and Cellular Cardiology | volume = 42 | issue = 3 | pages = 572–81 | date = Mar 2007 | pmid = 17276456 | doi = 10.1016/j.yjmcc.2006.11.018 | pmc=1983066}}
14. ^{{cite journal | vauthors = Metral S, Machnicka B, Bigot S, Colin Y, Dhermy D, Lecomte MC | title = AlphaII-spectrin is critical for cell adhesion and cell cycle | journal = The Journal of Biological Chemistry | volume = 284 | issue = 4 | pages = 2409–18 | date = Jan 2009 | pmid = 18978357 | doi = 10.1074/jbc.M801324200 }}
15. ^{{cite journal | vauthors = Sridharan DM, McMahon LW, Lambert MW | title = alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus | journal = Cell Biology International | volume = 30 | issue = 11 | pages = 866–78 | date = Nov 2006 | pmid = 16889989 | doi = 10.1016/j.cellbi.2006.06.005 }}
16. ^{{cite journal | vauthors = Nedrelow JH, Cianci CD, Morrow JS | title = c-Src binds alpha II spectrin's Src homology 3 (SH3) domain and blocks calpain susceptibility by phosphorylating Tyr1176 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7735–41 | date = Feb 2003 | pmid = 12446661 | doi = 10.1074/jbc.M210988200 }}
17. ^{{cite journal | vauthors = Kennedy SP, Warren SL, Forget BG, Morrow JS | title = Ankyrin binds to the 15th repetitive unit of erythroid and nonerythroid beta-spectrin | journal = The Journal of Cell Biology | volume = 115 | issue = 1 | pages = 267–77 | date = Oct 1991 | pmid = 1833409 | doi=10.1083/jcb.115.1.267 | pmc=2289929}}
18. ^{{cite journal | vauthors = Moorthy S, Chen L, Bennett V | title = Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function | journal = The Journal of Cell Biology | volume = 149 | issue = 4 | pages = 915–30 | date = May 2000 | pmid = 10811831 | doi=10.1083/jcb.149.4.915 | pmc=2174577}}
19. ^{{cite journal | vauthors = Wang XF, Gao GD, Liu J, Guo R, Lin YX, Chu YL, Han FC, Zhang WH, Bai YJ | title = Identification of differentially expressed genes induced by angiotensin II in rat cardiac fibroblasts | journal = Clinical and Experimental Pharmacology & Physiology | volume = 33 | issue = 1–2 | pages = 41–6 | date = 2006 | pmid = 16445697 | doi = 10.1111/j.1440-1681.2006.04321.x }}
20. ^{{cite journal | vauthors = Weiss ES, Wang KK, Allen JG, Blue ME, Nwakanma LU, Liu MC, Lange MS, Berrong J, Wilson MA, Gott VL, Troncoso JC, Hayes RL, Johnston MV, Baumgartner WA | title = Alpha II-spectrin breakdown products serve as novel markers of brain injury severity in a canine model of hypothermic circulatory arrest | journal = The Annals of Thoracic Surgery | volume = 88 | issue = 2 | pages = 543–50 | date = Aug 2009 | pmid = 19632410 | doi = 10.1016/j.athoracsur.2009.04.016 | pmc=3412404}}
21. ^{{cite journal | vauthors = Writzl K, Primec ZR, Stražišar BG, Osredkar D, Pečarič-Meglič N, Kranjc BS, Nishiyama K, Matsumoto N, Saitsu H | title = Early onset West syndrome with severe hypomyelination and coloboma-like optic discs in a girl with SPTAN1 mutation | journal = Epilepsia | volume = 53 | issue = 6 | pages = e106–10 | date = Jun 2012 | pmid = 22429196 | doi = 10.1111/j.1528-1167.2012.03437.x }}
22. ^{{cite journal | vauthors = Jain P, Spaeder MC, Donofrio MT, Sinha P, Jonas RA, Levy RJ | title = Detection of alpha II-spectrin breakdown products in the serum of neonates with congenital heart disease* | journal = Pediatric Critical Care Medicine | volume = 15 | issue = 3 | pages = 229–35 | date = Mar 2014 | pmid = 24395002 | doi = 10.1097/PCC.0000000000000059 | pmc=4059536}}
23. ^{{cite journal | vauthors = Lehmensiek V, Süssmuth SD, Brettschneider J, Tauscher G, Felk S, Gillardon F, Tumani H | title = Proteome analysis of cerebrospinal fluid in Guillain–Barré syndrome (GBS) | journal = Journal of Neuroimmunology | volume = 185 | issue = 1–2 | pages = 190–4 | date = Apr 2007 | pmid = 17367871 | doi = 10.1016/j.jneuroim.2007.01.022 }}
24. ^{{cite journal | vauthors = Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L | title = Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton | journal = J. Biol. Chem. | volume = 273 | issue = 22 | pages = 13681–92 | date = May 1998 | pmid = 9593709 | doi = 10.1074/jbc.273.22.13681}}
25. ^{{cite journal | vauthors = Sridharan D, Brown M, Lambert WC, McMahon LW, Lambert MW | title = Nonerythroid alphaII spectrin is required for recruitment of FANCA and XPF to nuclear foci induced by DNA interstrand cross-links | journal = J. Cell Sci. | volume = 116 | issue = Pt 5 | pages = 823–35 | date = March 2003 | pmid = 12571280 | doi = 10.1242/jcs.00294}}
26. ^1 {{cite journal | vauthors = McMahon LW, Sangerman J, Goodman SR, Kumaresan K, Lambert MW | title = Human alpha spectrin II and the FANCA, FANCC, and FANCG proteins bind to DNA containing psoralen interstrand cross-links | journal = Biochemistry | volume = 40 | issue = 24 | pages = 7025–34 | date = June 2001 | pmid = 11401546 | doi = 10.1021/bi002917g}}
27. ^1 {{cite journal | vauthors = McMahon LW, Walsh CE, Lambert MW | title = Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex | journal = J. Biol. Chem. | volume = 274 | issue = 46 | pages = 32904–8 | date = November 1999 | pmid = 10551855 | doi = 10.1074/jbc.274.46.32904}}
28. ^{{cite journal | vauthors = Hirai H, Matsuda S | title = Interaction of the C-terminal domain of delta glutamate receptor with spectrin in the dendritic spines of cultured Purkinje cells | journal = Neurosci. Res. | volume = 34 | issue = 4 | pages = 281–7 | date = September 1999 | pmid = 10576550 | doi = 10.1016/s0168-0102(99)00061-9}}
29. ^{{cite journal | vauthors = Herrmann H, Wiche G | title = Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin | journal = J. Biol. Chem. | volume = 262 | issue = 3 | pages = 1320–5 | date = January 1987 | pmid = 3027087 | doi = }}
30. ^{{cite journal | vauthors = Böckers TM, Mameza MG, Kreutz MR, Bockmann J, Weise C, Buck F, Richter D, Gundelfinger ED, Kreienkamp HJ | title = Synaptic scaffolding proteins in rat brain. Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein alpha-fodrin | journal = J. Biol. Chem. | volume = 276 | issue = 43 | pages = 40104–12 | date = October 2001 | pmid = 11509555 | doi = 10.1074/jbc.M102454200 }}
31. ^1 {{cite journal | vauthors = Brown MJ, Hallam JA, Liu Y, Yamada KM, Shaw S | title = Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin | journal = J. Immunol. | volume = 167 | issue = 2 | pages = 641–5 | date = July 2001 | pmid = 11441066 | doi = 10.4049/jimmunol.167.2.641}}

Further reading

{{Refbegin|33em}}
  • {{cite journal | vauthors = Chow CW | title = Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3. | journal = Clinical and Investigative Medicine. Médecine Clinique et Experimentale | volume = 22 | issue = 5 | pages = 195–206 | year = 1999 | pmid = 10579058 | doi = }}
  • {{cite journal | vauthors = Hayashi Y, Arakaki R, Ishimaru N | title = The role of caspase cascade on the development of primary Sjögren's syndrome. | journal = J. Med. Invest. | volume = 50 | issue = 1–2 | pages = 32–8 | year = 2003 | pmid = 12630566 | doi = }}
  • {{cite journal | vauthors = Bennett V | title = Immunoreactive forms of human erythrocyte ankyrin are present in diverse cells and tissues. | journal = Nature | volume = 281 | issue = 5732 | pages = 597–9 | year = 1979 | pmid = 492324 | doi = 10.1038/281597a0 }}
  • {{cite journal | vauthors = Frappier T, Stetzkowski-Marden F, Pradel LA | title = Interaction domains of neurofilament light chain and brain spectrin. | journal = Biochem. J. | volume = ( Pt 2) | issue = 2| pages = 521–7 | year = 1991 | pmid = 1902666 | pmc = 1150082 | doi = 10.1042/bj2750521| series = 275 }}
  • {{cite journal | vauthors = Bennett AF, Hayes NV, Baines AJ | title = Site specificity in the interactions of synapsin 1 with tubulin. | journal = Biochem. J. | volume = ( Pt 3) | issue = 3| pages = 793–9 | year = 1991 | pmid = 1905928 | pmc = 1151074 | doi = 10.1042/bj2760793| series = 276 }}
  • {{cite journal | vauthors = Davis LH, Bennett V | title = Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. | journal = J. Biol. Chem. | volume = 265 | issue = 18 | pages = 10589–96 | year = 1990 | pmid = 2141335 | doi = }}
  • {{cite journal | vauthors = Moon RT, McMahon AP | title = Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin. | journal = J. Biol. Chem. | volume = 265 | issue = 8 | pages = 4427–33 | year = 1990 | pmid = 2307671 | doi = }}
  • {{cite journal | vauthors = Langley RC, Cohen CM | title = Association of spectrin with desmin intermediate filaments. | journal = J. Cell. Biochem. | volume = 30 | issue = 2 | pages = 101–9 | year = 1986 | pmid = 2939097 | doi = 10.1002/jcb.240300202 }}
  • {{cite journal | vauthors = Cianci CD, Giorgi M, Morrow JS | title = Phosphorylation of ankyrin down-regulates its cooperative interaction with spectrin and protein 3. | journal = J. Cell. Biochem. | volume = 37 | issue = 3 | pages = 301–15 | year = 1988 | pmid = 2970468 | doi = 10.1002/jcb.240370305 }}
  • {{cite journal | vauthors = Steiner JP, Bennett V | title = Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin. | journal = J. Biol. Chem. | volume = 263 | issue = 28 | pages = 14417–25 | year = 1988 | pmid = 2971657 | doi = }}
  • {{cite journal | vauthors = Herrmann H, Wiche G | title = Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin. | journal = J. Biol. Chem. | volume = 262 | issue = 3 | pages = 1320–5 | year = 1987 | pmid = 3027087 | doi = }}
  • {{cite journal | vauthors = McMahon AP, Giebelhaus DH, Champion JE, Bailes JA, Lacey S, Carritt B, Henchman SK, Moon RT | title = cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin. | journal = Differentiation | volume = 34 | issue = 1 | pages = 68–78 | year = 1987 | pmid = 3038643 | doi = 10.1111/j.1432-0436.1987.tb00052.x }}
  • {{cite journal | vauthors = Frappier T, Regnouf F, Pradel LA | title = Binding of brain spectrin to the 70-kDa neurofilament subunit protein. | journal = Eur. J. Biochem. | volume = 169 | issue = 3 | pages = 651–7 | year = 1988 | pmid = 3121319 | doi = 10.1111/j.1432-1033.1987.tb13657.x }}
  • {{cite journal | vauthors = McMahon AP, Moon RT | title = Structure and evolution of a non-erythroid spectrin, human alpha-fodrin. | journal = Biochem. Soc. Trans. | volume = 15 | issue = 5 | pages = 804–7 | year = 1988 | pmid = 3691949 | doi = 10.1042/bst0150804}}
  • {{cite journal | vauthors = Lundberg S, Björk J, Löfvenberg L, Backman L | title = Cloning, expression and characterization of two putative calcium-binding sites in human non-erythroid alpha-spectrin. | journal = Eur. J. Biochem. | volume = 230 | issue = 2 | pages = 658–65 | year = 1995 | pmid = 7607240 | doi = 10.1111/j.1432-1033.1995.0658h.x }}
  • {{cite journal | vauthors = Hughes CA, Bennett V | title = Adducin: a physical model with implications for function in assembly of spectrin-actin complexes. | journal = J. Biol. Chem. | volume = 270 | issue = 32 | pages = 18990–6 | year = 1995 | pmid = 7642559 | doi = 10.1074/jbc.270.32.18990 }}
  • {{cite journal | vauthors = Gregorio CC, Repasky EA, Fowler VM, Black JD | title = Dynamic properties of ankyrin in T lymphocytes: colocalization with spectrin and protein kinase C beta. | journal = J. Cell Biol. | volume = 125 | issue = 2 | pages = 345–58 | year = 1994 | pmid = 8163551 | pmc = 2120020 | doi = 10.1083/jcb.125.2.345 }}
  • {{cite journal | vauthors = Li X, Bennett V | title = Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes. | journal = J. Biol. Chem. | volume = 271 | issue = 26 | pages = 15695–702 | year = 1996 | pmid = 8663089 | doi = 10.1074/jbc.271.26.15695 }}
  • {{cite journal | vauthors = Stabach PR, Cianci CD, Glantz SB, Zhang Z, Morrow JS | title = Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility. | journal = Biochemistry | volume = 36 | issue = 1 | pages = 57–65 | year = 1997 | pmid = 8993318 | doi = 10.1021/bi962034i }}
{{Refend}}{{PDB Gallery|geneid=6709}}{{Cytoskeletal Proteins}}

1 : EF-hand-containing proteins
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/12 12:52:23