MI6 is the United Kingdom's Secret Intelligence Service.

MI-6 or MI6 may also refer to:

• AMD's MI6, a brand of deep learning oriented Graphics Processing Units, see Radeon Instinct
• Mil Mi-6, a Soviet built transport helicopter
• Michigan's 6th congressional district
• M-6 (Michigan highway)
• MI6.co.uk, former website of the media-website MI6-HQ.com
• Impossible – Fallout, a 2018 spy-thriller film starring Tom Cruise
• Xiaomi Mi 6, a smartphone developed by Xiaomi Inc.

• Afe Babalola University, Ado-Ekiti (ABUAD) Faculty of Law
• Afe Babalola University, Ado-Ekiti (ABUAD) Faculty of Sciences
• Afe Babalola University Faculty of Sciences
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• A.Fedtsch.
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• AFEE
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• Afemai
• Afemai language
• Afeman, Louisiana