请输入您要查询的百科知识：

　

词条 SS18
释义

  1. Function

  2. Clinical significance

  3. Interactions

  4. References

  5. Further reading

{{Infobox_gene}}Protein SSXT is a protein that in humans is encoded by the SS18 gene.[1][2][3]

Function

SS18 is a member of the human SWI/SNF chromatin remodeling complex.[4][5][6]

Clinical significance

SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma.[5]

Interactions

SS18 has been shown to interact with:

{{div col|colwidth=20em}}
  • EP300,[6]
  • MLLT10,[7]
  • SMARCA2,[8] and
  • SMARCB1.[9]
{{Div col end}}

References

1. ^{{cite journal | vauthors = Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA | title = The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome | journal = Oncogene | volume = 9 | issue = 5 | pages = 1447–53 | date = May 1994 | pmid = 8152806 | doi = }}
2. ^{{cite journal | vauthors = Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS | title = Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma | journal = Nature Genetics | volume = 7 | issue = 4 | pages = 502–8 | date = Aug 1994 | pmid = 7951320 | pmc = | doi = 10.1038/ng0894-502 }}
3. ^{{cite journal | vauthors = de Bruijn DR, Geurts van Kessel A | title = Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci | journal = Cytogenetic and Genome Research | volume = 112 | issue = 3–4 | pages = 222–6 | year = 2006 | pmid = 16484776 | doi = 10.1159/000089874 }}
4. ^{{cite journal | vauthors = Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C | title = SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes | journal = PLOS ONE | volume = 7 | issue = 3 | pages = e33834 | year = 2012 | pmid = 22442726 | pmc = 3307773 | doi = 10.1371/journal.pone.0033834 }}
5. ^{{cite journal | vauthors = Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O | title = Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas | journal = Oncogene | volume = 21 | issue = 26 | pages = 4181–90 | date = Jun 2002 | pmid = 12037676 | doi = 10.1038/sj.onc.1205569 }}
6. ^{{cite journal | vauthors = Eid JE, Kung AL, Scully R, Livingston DM | title = p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion | journal = Cell | volume = 102 | issue = 6 | pages = 839–48 | date = Sep 2000 | pmid = 11030627 | doi = 10.1016/S0092-8674(00)00072-6 }}
7. ^{{cite journal | vauthors = de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A | title = The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10 | journal = Oncogene | volume = 20 | issue = 25 | pages = 3281–9 | date = May 2001 | pmid = 11423977 | doi = 10.1038/sj.onc.1204419 }}
8. ^1 {{cite journal | vauthors = Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH | title = Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers | journal = Oncogene | volume = 22 | issue = 50 | pages = 8156–67 | date = Nov 2003 | pmid = 14603256 | doi = 10.1038/sj.onc.1207031 }}
9. ^1 {{cite journal | vauthors = Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG | title = SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 5498–505 | date = Feb 2002 | pmid = 11734557 | doi = 10.1074/jbc.M108702200 }}

Further reading

{{Refbegin | 2}}
  • {{cite journal | vauthors = Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M | title = Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript | journal = The American Journal of Pathology | volume = 147 | issue = 6 | pages = 1592–9 | date = Dec 1995 | pmid = 7495284 | pmc = 1869933 | doi = }}
  • {{cite journal | vauthors = Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G | title = The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies | journal = Human Molecular Genetics | volume = 6 | issue = 9 | pages = 1559–64 | date = Sep 1997 | pmid = 9285794 | doi = 10.1093/hmg/6.9.1559 }}
  • {{cite journal | vauthors = Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, Cooper CS, Goodwin G | title = Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus | journal = Human Molecular Genetics | volume = 8 | issue = 4 | pages = 585–91 | date = Apr 1999 | pmid = 10072425 | doi = 10.1093/hmg/8.4.585 }}
  • {{cite journal | vauthors = Eid JE, Kung AL, Scully R, Livingston DM | title = p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion | journal = Cell | volume = 102 | issue = 6 | pages = 839–48 | date = Sep 2000 | pmid = 11030627 | doi = 10.1016/S0092-8674(00)00072-6 }}
  • {{cite journal | vauthors = Tamborini E, Agus V, Mezzelani A, Riva C, Sozzi G, Azzarelli A, Pierotti MA, Pilotti S | title = Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma | journal = British Journal of Cancer | volume = 84 | issue = 8 | pages = 1087–94 | date = Apr 2001 | pmid = 11308259 | pmc = 2363857 | doi = 10.1054/bjoc.2000.1710 }}
  • {{cite journal | vauthors = Brodin B, Haslam K, Yang K, Bartolazzi A, Xie Y, Starborg M, Lundeberg J, Larsson O | title = Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression | journal = Gene | volume = 268 | issue = 1–2 | pages = 173–82 | date = May 2001 | pmid = 11368913 | doi = 10.1016/S0378-1119(01)00412-7 }}
  • {{cite journal | vauthors = de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A | title = The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10 | journal = Oncogene | volume = 20 | issue = 25 | pages = 3281–9 | date = May 2001 | pmid = 11423977 | doi = 10.1038/sj.onc.1204419 }}
  • {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65 | date = Oct 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 | url = http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/50027/1/2_1758.full.pdf }}
  • {{cite journal | vauthors = Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG | title = SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 5498–505 | date = Feb 2002 | pmid = 11734557 | doi = 10.1074/jbc.M108702200 }}
  • {{cite journal | vauthors = Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O | title = Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas | journal = Oncogene | volume = 21 | issue = 26 | pages = 4181–90 | date = Jun 2002 | pmid = 12037676 | doi = 10.1038/sj.onc.1205569 }}
  • {{cite journal | vauthors = Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A | title = Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis | journal = Experimental Cell Research | volume = 288 | issue = 1 | pages = 35–50 | date = Aug 2003 | pmid = 12878157 | doi = 10.1016/S0014-4827(03)00130-7 }}
  • {{cite journal | vauthors = Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH | title = Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers | journal = Oncogene | volume = 22 | issue = 50 | pages = 8156–67 | date = Nov 2003 | pmid = 14603256 | doi = 10.1038/sj.onc.1207031 }}
  • {{cite journal | vauthors = Iwasaki T, Koibuchi N, Chin WW | title = Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator | journal = Endocrinology | volume = 146 | issue = 9 | pages = 3892–9 | date = Sep 2005 | pmid = 15919756 | doi = 10.1210/en.2004-1513 }}
  • {{cite journal | vauthors = Fernebro J, Francis P, Edén P, Borg A, Panagopoulos I, Mertens F, Vallon-Christersson J, Akerman M, Rydholm A, Bauer HC, Mandahl N, Nilbert M | title = Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma | journal = International Journal of Cancer | volume = 118 | issue = 5 | pages = 1165–72 | date = Mar 2006 | pmid = 16152617 | doi = 10.1002/ijc.21475 }}
  • {{cite journal | vauthors = Perani M, Antonson P, Hamoudi R, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH | title = The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins | journal = The Journal of Biological Chemistry | volume = 280 | issue = 52 | pages = 42863–76 | date = Dec 2005 | pmid = 16227627 | doi = 10.1074/jbc.M502963200 }}
  • {{cite journal | vauthors = Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S | title = IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1 | journal = Oncogene | volume = 25 | issue = 7 | pages = 1042–52 | date = Feb 2006 | pmid = 16247461 | doi = 10.1038/sj.onc.1209143 }}
{{Refend}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/13 11:20:43