| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, also known as sialyltransferase 3C (SIAT3-C) or sialyltransferase 7D (SIAT7-D) is a sialyltransferase enzyme that in humans is encoded by the ST6GALNAC4 gene.[1] Function ST6GALNAC4 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The enzyme is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene.[1] References1. ^1 {{cite web | title = Entrez Gene: ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27090| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Lanfranchi G, Muraro T, Caldara F, etal |title=Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization. |journal=Genome Res. |volume=6 |issue= 1 |pages= 35–42 |year= 1996 |pmid= 8681137 |doi=10.1101/gr.6.1.35 }}
- {{cite journal |vauthors=Lee YC, Kaufmann M, Kitazume-Kawaguchi S, etal |title=Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11958–67 |year= 1999 |pmid= 10207017 |doi=10.1074/jbc.274.17.11958 }}
- {{cite journal | vauthors=Gilley J, Fried M |title=Extensive gene order differences within regions of conserved synteny between the Fugu and human genomes: implications for chromosomal evolution and the cloning of disease genes. |journal=Hum. Mol. Genet. |volume=8 |issue= 7 |pages= 1313–20 |year= 1999 |pmid= 10369878 |doi=10.1093/hmg/8.7.1313 }}
- {{cite journal |vauthors=Harduin-Lepers A, Stokes DC, Steelant WF, etal |title=Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV. |journal=Biochem. J. |volume=352 Pt 1 |issue= |pages= 37–48 |year= 2001 |pmid= 11062056 |doi= | pmc=1221430 }}
- {{cite journal |vauthors=Moody AM, North SJ, Reinhold B, etal |title=Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7240–6 |year= 2003 |pmid= 12459555 |doi= 10.1074/jbc.M210468200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Kim SW, Kang NY, Lee SH, etal |title=Genomic structure and promoter analysis of human NeuAc alpha2,3Gal beta1,3GalNAc alpha2,6-sialyltransferase (hST6GalNAc IV) gene. |journal=Gene |volume=305 |issue= 1 |pages= 113–20 |year= 2003 |pmid= 12594047 |doi=10.1016/S0378-1119(02)01234-9 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Kang NY, Park YD, Choi HJ, etal |title=Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene. |journal=Mol. Cells |volume=18 |issue= 2 |pages= 157–62 |year= 2005 |pmid= 15528990 |doi= }}
- {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
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