| 释义 |
- Function
- Interactions
- References
- Further reading
{{about|the protein and gene|the microcontroller|ST6/ST7|Star Trek VII|Star Trek Generations|other uses}}{{Infobox_gene}}Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7 gene.[1][2][3] ST7 orthologs [4] have been identified in all mammals for which complete genome data are available. Function The gene for this product maps to a region on human chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described.[3] Interactions ST7 has been shown to interact with ITGB1BP3[5] and GNB2L1.[5] References 1. ^{{cite journal | vauthors = Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M | title = Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1 | journal = Molecular and Cellular Biology | volume = 13 | issue = 10 | pages = 6036–43 | date = October 1993 | pmid = 8105370 | pmc = 364663 | doi = 10.1128/mcb.13.10.6036}}
2. ^{{cite journal | vauthors = Zenklusen JC, Rodriguez LV, LaCava M, Wang Z, Goldstein LS, Conti CJ | title = Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene | journal = Genome Research | volume = 6 | issue = 11 | pages = 1070–6 | date = November 1996 | pmid = 8938430 | pmc = | doi = 10.1101/gr.6.11.1070 }}
3. ^1 {{cite web | title = Entrez Gene: ST7 suppression of tumorigenicity 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7982| accessdate = }}
4. ^{{cite web | title = OrthoMaM phylogenetic marker: ST7 coding sequence | url = http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000004866_ST7.xml }}
5. ^1 {{cite journal | vauthors = Battle MA, Maher VM, McCormick JJ | title = ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways | journal = Biochemistry | volume = 42 | issue = 24 | pages = 7270–82 | date = June 2003 | pmid = 12809483 | doi = 10.1021/bi034081y }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Zenklusen JC, Weitzel JN, Ball HG, Conti CJ | title = Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene | journal = Oncogene | volume = 11 | issue = 2 | pages = 359–63 | date = July 1995 | pmid = 7624150 | doi = }}
- {{cite journal | vauthors = Zenklusen JC, Thompson JC, Troncoso P, Kagan J, Conti CJ | title = Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1 | journal = Cancer Research | volume = 54 | issue = 24 | pages = 6370–3 | date = December 1994 | pmid = 7987830 | doi = }}
- {{cite journal | vauthors = Zenklusen JC, Bièche I, Lidereau R, Conti CJ | title = (C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 25 | pages = 12155–8 | date = December 1994 | pmid = 7991599 | pmc = 45395 | doi = 10.1073/pnas.91.25.12155 }}
- {{cite journal | vauthors = Folstein SE, Mankoski RE | title = Chromosome 7q: where autism meets language disorder? | journal = American Journal of Human Genetics | volume = 67 | issue = 2 | pages = 278–81 | date = August 2000 | pmid = 10889044 | pmc = 1287175 | doi = 10.1086/303034 }}
- {{cite journal | vauthors = Vincent JB, Herbrick JA, Gurling HM, Bolton PF, Roberts W, Scherer SW | title = Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual | journal = American Journal of Human Genetics | volume = 67 | issue = 2 | pages = 510–4 | date = August 2000 | pmid = 10889047 | pmc = 1287197 | doi = 10.1086/303005 }}
- {{cite journal | vauthors = Zenklusen JC, Conti CJ, Green ED | title = Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31 | journal = Nature Genetics | volume = 27 | issue = 4 | pages = 392–8 | date = April 2001 | pmid = 11279520 | doi = 10.1038/86891 }}
- {{cite journal | vauthors = Brown VL, Proby CM, Barnes DM, Kelsell DP | title = Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours | journal = British Journal of Cancer | volume = 87 | issue = 2 | pages = 208–11 | date = July 2002 | pmid = 12107844 | pmc = 2376116 | doi = 10.1038/sj.bjc.6600418 }}
- {{cite journal | vauthors = Vincent JB, Petek E, Thevarkunnel S, Kolozsvari D, Cheung J, Patel M, Scherer SW | title = The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system | journal = Genomics | volume = 80 | issue = 3 | pages = 283–94 | date = September 2002 | pmid = 12213198 | doi = 10.1006/geno.2002.6835 }}
- {{cite journal | vauthors = Dong SM, Sidransky D | title = Absence of ST7 gene alterations in human cancer | journal = Clinical Cancer Research | volume = 8 | issue = 9 | pages = 2939–41 | date = September 2002 | pmid = 12231539 | doi = }}
- {{cite journal | vauthors = Wang S, Mori Y, Sato F, Yin J, Xu Y, Zou TT, Olaru A, Kimos MC, Perry K, Selaru FM, Deacu E, Sun M, Shi YC, Shibata D, Abraham JM, Greenwald BD, Meltzer SJ | title = An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma | journal = Oncogene | volume = 22 | issue = 3 | pages = 467–70 | date = January 2003 | pmid = 12545169 | doi = 10.1038/sj.onc.1206125 }}
- {{cite journal | vauthors = Battle MA, Maher VM, McCormick JJ | title = ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways | journal = Biochemistry | volume = 42 | issue = 24 | pages = 7270–82 | date = June 2003 | pmid = 12809483 | doi = 10.1021/bi034081y }}
- {{cite journal | vauthors = Sivasundaram K, Suzuki H, Seto M, Hosokawa Y | title = Mutational analysis of the ST7 gene in human myeloid tumor cell lines | journal = Oncology Reports | volume = 10 | issue = 6 | pages = 1737–9 | year = 2004 | pmid = 14534688 | doi = 10.3892/or.10.6.1737 }}
- {{cite journal | vauthors = Lu C, Xu HM, Ren Q, Ao Y, Wang ZN, Ao X, Jiang L, Luo Y, Zhang X | title = Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC | journal = World Journal of Gastroenterology | volume = 9 | issue = 12 | pages = 2662–5 | date = December 2003 | pmid = 14669308 | doi = 10.3748/wjg.v9.i12.2662}}
- {{cite journal | vauthors = Liu J, Gough J, Rost B | title = Distinguishing protein-coding from non-coding RNAs through support vector machines | journal = PLoS Genetics | volume = 2 | issue = 4 | pages = e29 | date = April 2006 | pmid = 16683024 | pmc = 1449884 | doi = 10.1371/journal.pgen.0020029 }} {{open access}}
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