“STAM2”的意思、由来-开放百科全书

Function

The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.^[3]

Interactions

STAM2 has been shown to interact with HGS,^[4]^[5] Janus kinase 1^[1]^[2] and USP8.^[6]^[7]

References

1. ^¹{{cite journal | vauthors = Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K | title = STAM2, a new member of the STAM family, binding to the Janus kinases | journal = FEBS Letters | volume = 477 | issue = 1-2 | pages = 55–61 | date = Jul 2000 | pmid = 10899310 | pmc = | doi = 10.1016/S0014-5793(00)01760-9 }}
2. ^¹{{cite journal | vauthors = Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF | title = Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways | journal = The Journal of Biological Chemistry | volume = 275 | issue = 49 | pages = 38633–9 | date = Dec 2000 | pmid = 10993906 | pmc = | doi = 10.1074/jbc.M007849200 }}
3. ^¹{{cite web | title = Entrez Gene: STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10254| accessdate = }}
4. ^{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
5. ^{{cite journal | vauthors = Bache KG, Raiborg C, Mehlum A, Stenmark H | title = STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 14 | pages = 12513–21 | date = Apr 2003 | pmid = 12551915 | doi = 10.1074/jbc.M210843200 }}
6. ^{{cite journal | vauthors = Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N | title = Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 48 | pages = 48162–8 | date = Nov 2003 | pmid = 13129930 | doi = 10.1074/jbc.M306677200 }}
7. ^{{cite journal | vauthors = Kato M, Miyazawa K, Kitamura N | title = A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal = The Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37481–7 | date = Dec 2000 | pmid = 10982817 | doi = 10.1074/jbc.M007251200 }}

Further reading

{{cite journal | vauthors = Sulman EP, Tang XX, Allen C, Biegel JA, Pleasure DE, Brodeur GM, Ikegaki N | title = ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers | journal = Genomics | volume = 40 | issue = 2 | pages = 371–4 | date = Mar 1997 | pmid = 9119409 | doi = 10.1006/geno.1996.4569 }}

{{cite journal | vauthors = Kato M, Miyazawa K, Kitamura N | title = A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP | journal = The Journal of Biological Chemistry | volume = 275 | issue = 48 | pages = 37481–7 | date = Dec 2000 | pmid = 10982817 | doi = 10.1074/jbc.M007251200 }}

{{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}

{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}

{{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}

{{cite journal | vauthors = Steen H, Kuster B, Fernandez M, Pandey A, Mann M | title = Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway | journal = The Journal of Biological Chemistry | volume = 277 | issue = 2 | pages = 1031–9 | date = Jan 2002 | pmid = 11687594 | doi = 10.1074/jbc.M109992200 }}

{{cite journal | vauthors = Bache KG, Raiborg C, Mehlum A, Stenmark H | title = STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 14 | pages = 12513–21 | date = Apr 2003 | pmid = 12551915 | doi = 10.1074/jbc.M210843200 }}

{{cite journal | vauthors = Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N | title = Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 48 | pages = 48162–8 | date = Nov 2003 | pmid = 13129930 | doi = 10.1074/jbc.M306677200 }}

{{cite journal | vauthors = Mizuno E, Kawahata K, Okamoto A, Kitamura N, Komada M | title = Association with Hrs is required for the early endosomal localization, stability, and function of STAM | journal = Journal of Biochemistry | volume = 135 | issue = 3 | pages = 385–96 | date = Mar 2004 | pmid = 15113837 | doi = 10.1093/jb/mvh046 }}

{{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–72 | date = May 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}

{{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}

{{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}

{{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}

{{cite journal | vauthors = Lechner MS, Schultz DC, Negorev D, Maul GG, Rauscher FJ | title = The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain | journal = Biochemical and Biophysical Research Communications | volume = 331 | issue = 4 | pages = 929–37 | date = Jun 2005 | pmid = 15882967 | doi = 10.1016/j.bbrc.2005.04.016 }}

Function

Interactions

References

Further reading

External links