| 词条 | Stanley Fields (biologist) |
| 释义 |
| name = Stan Fields | birth_name = Stanley Fields | native_name_lang = | image = | image_size = | alt = | caption = | birth_date = | birth_place = | death_date = | death_place = | resting_place = | resting_place_coordinates = | other_names = | residence = | citizenship = | nationality = | fields = | workplaces = {{Plainlist|
| patrons = | alma_mater = University of Cambridge | thesis_title = Sequence analysis of influenza virus RNA | thesis_url = http://ulmss-newton.lib.cam.ac.uk/vwebv/holdingsInfo?bibId=8289 | thesis_year = 1981 | doctoral_advisor = | academic_advisors = | doctoral_students = | notable_students = | known_for = Two-hybrid screening | influences = | influenced = | awards = | signature = | signature_alt = | website = {{Plainlist|
| footnotes = | spouse = | children = }}Stanley Fields is an American biologist best known for developing the yeast two hybrid method for identifying protein–protein interactions.[1] He is currently a professor of Genome Sciences at the University of Washington and Howard Hughes Medical Institute Investigator.[2][3] EducationFields was educated at the University of Cambridge where he was awarded a Doctor of Philosophy in 1981 for research carried out in the Laboratory of Molecular Biology (LMB) with Greg Winter and George Brownlee.[4][5] ResearchAlong with Matt Kaeberlein and Brian Kennedy, Fields has carried out genome-wide screens for aging genes in yeast. Kaeberlein and co-workers have questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins.[6] Instead Kaeberlein, Fields, and Kennedy have proposed that caloric restriction increases lifespan by decreasing the activity of the Target of Rapamycin (TOR) kinase.[7] Honors and awards
References1. ^{{Cite journal| volume = 340| title = A novel genetic system to detect protein-protein interactions| issue = 6230| pages = 245–246| journal = Nature | first2 = O.| last2 = Song| pmid = 2547163| year = 1989| last1 = Fields | first1 = S.| doi = 10.1038/340245a0 |bibcode = 1989Natur.340..245F }} {{Portal|Biography}}{{authority control}}{{DEFAULTSORT:Fields, Stanley}}{{US-biologist-stub}}2. ^{{Cite journal | doi = 10.1534/genetics.114.165134| pmid = 24939989| title = Would Fred Sanger Get Funded Today?| journal = Genetics| volume = 197| issue = 2| pages = 435–439| year = 2014| last1 = Fields | first1 = Stanley| authorlink1 = Stanley Fields (biologist)| pmc=4063904}} 3. ^{{Scopus|id=7102919472}} 4. ^{{Cite journal | doi = 10.1038/292072a0| pmid = 7278968| title = Nucleotide sequence of the haemagglutinin gene of a human influenza virus H1 subtype| journal = Nature| volume = 292| issue = 5818| pages = 72| year = 1981| last1 = Winter | first1 = G. | authorlink1 = Greg Winter| last2 = Fields | first2 = S. | authorlink2 = Stanley Fields (biologist)| last3 = Brownlee | first3 = G. G. | authorlink3 = George Brownlee| bibcode = 1981Natur.292...72W}} 5. ^{{Cite journal | doi = 10.1038/290213a0| pmid = 7010182| title = Structure of the neuraminidase gene in human influenza virus A/PR/8/34| journal = Nature| volume = 290| issue = 5803| pages = 213| year = 1981| last1 = Fields | first1 = S. | authorlink1 = Stanley Fields (biologist)| last2 = Winter | first2 = G. | authorlink2 = Greg Winter| last3 = Brownlee | first3 = G. G. | authorlink3 = George Brownlee| bibcode = 1981Natur.290..213F}} 6. ^{{Cite journal | doi = 10.1371/journal.pbio.0020296| pmid = 15328540| title = Sir2-Independent Life Span Extension by Calorie Restriction in Yeast| journal = PLoS Biology| volume = 2| issue = 9| pages = e296| year = 2004| last1 = Kaeberlein | first1 = M. | last2 = Kirkland | first2 = K. T. | last3 = Fields | first3 = S. | last4 = Kennedy | first4 = B. K. | pmc=514491}} 7. ^{{Cite journal | pmid = 16293764| year = 2005| author1 = Kaeberlein| first1 = M| title = Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients| journal = Science| volume = 310| issue = 5751| pages = 1193–6| last2 = Powers Rw| first2 = 3rd| last3 = Steffen| first3 = K. K.| last4 = Westman| first4 = E. A.| last5 = Hu| first5 = D| last6 = Dang| first6 = N| last7 = Kerr| first7 = E. O.| last8 = Kirkland| first8 = K. T.| last9 = Fields| first9 = S| last10 = Kennedy| first10 = B. K.| doi = 10.1126/science.1115535| bibcode = 2005Sci...310.1193K}} 8. ^http://www.brandeis.edu/rosenstiel/gabbayaward/past.html 7 : 1955 births|Members of the United States National Academy of Sciences|Living people|American molecular biologists|American geneticists|University of Washington faculty|Howard Hughes Medical Investigators |
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