| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Signal-transducing adaptor protein 2 is a protein that in humans is encoded by the STAP2 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.[3]
}}InteractionsSTAP2 has been shown to interact with PTK6.[1] References1. ^1 {{cite journal | vauthors = Mitchell PJ, Sara EA, Crompton MR | title = A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK | journal = Oncogene | volume = 19 | issue = 37 | pages = 4273–82 |date=Oct 2000 | pmid = 10980601 | pmc = | doi = 10.1038/sj.onc.1203775 }}
2. ^{{cite journal | vauthors = Dehal P, Predki P, Olsen AS, Kobayashi A, Folta P, Lucas S, Land M, Terry A, Ecale Zhou CL, Rash S, Zhang Q, Gordon L, Kim J, Elkin C, Pollard MJ, Richardson P, Rokhsar D, Uberbacher E, Hawkins T, Branscomb E, Stubbs L | title = Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution | journal = Science | volume = 293 | issue = 5527 | pages = 104–11 |date=Jul 2001 | pmid = 11441184 | pmc = | doi = 10.1126/science.1060310 }}
3. ^1 {{cite web | title = Entrez Gene: STAP2 signal-transducing adaptor protein-2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55620| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Rosenzweig BL, Imamura T, Okadome T, etal |title=Cloning and characterization of a human type II receptor for bone morphogenetic proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7632–6 |year= 1995 |pmid= 7644468 |doi=10.1073/pnas.92.17.7632 | pmc=41199 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Minoguchi M, Minoguchi S, Aki D, etal |title=STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11182–9 |year= 2003 |pmid= 12540842 |doi= 10.1074/jbc.M211230200 }}
- {{cite journal |vauthors=Yamamoto T, Yumioka T, Sekine Y, etal |title=Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 3 |pages= 767–73 |year= 2003 |pmid= 12810085 |doi=10.1016/S0006-291X(03)01042-8 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Sekine Y, Yamamoto T, Yumioka T, etal |title=Physical and functional interactions between STAP-2/BKS and STAT5. |journal=J. Biol. Chem. |volume=280 |issue= 9 |pages= 8188–96 |year= 2005 |pmid= 15611091 |doi= 10.1074/jbc.M411692200 }}
- {{cite journal |vauthors=Sekine Y, Tsuji S, Ikeda O, etal |title=Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase. |journal=J. Immunol. |volume=179 |issue= 4 |pages= 2397–407 |year= 2007 |pmid= 17675501 |doi= 10.4049/jimmunol.179.4.2397}}
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