| 词条 | Sticky platelet syndrome |
| 释义 |
| name = | synonym = | image = | image_size = | alt = | caption = | pronounce = | specialty = hematology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} Sticky platelet syndrome is a term used by some [1][2][3][4] to describe a disorder of platelet function.[5] It was first described by Mammen in 1983.[6] It is inherited in an autosomal dominant pattern.[7] It has not been associated with a specific gene, and it is not recognized as an entity in OMIM. Among researchers using the term, it has been described as a coagulation disorder that can present in conjunction with protein S deficiency and Factor V Leiden.[8] It is not currently known if sticky platelet syndrome is a distinct condition, or if it represents part of the presentation of a more well characterized coagulation disorder. CauseThe syndrome is believed to be hereditary. DiagnosisSPS is diagnosed by demonstrating platelet hyperaggregability. In a lab test called aggregometry platelet stickyness is stimulated with epinephrine (EPI) and/or adenosine diphosphate (ADP).[9] This test is not possible for patients being treated with acetylsalicylic acid until that substance has sufficiently cleared from their system.{{citation needed|date=March 2019}} TreatmentThose diagnosed are usually treated with taking a low dose (80–100 mg) Aspirin a day.[10] Anticoagulants (e.g. Warfarin, Coumadin) or clopidogrel (Plavix) are often additionally prescribed following formation of a medically significant clot. Thrombelastography is more commonly being used to diagnose hypercoagulability and monitor anti-platelet therapy.{{citation needed|date=March 2019}} See also
References1. ^{{Cite journal|author=Mammen EF |title=Sticky platelet syndrome |journal=Semin. Thromb. Hemost. |volume=25 |issue=4 |pages=361–5 |year=1999 |pmid=10548069 |doi= 10.1055/s-2007-994939|url=}} 2. ^{{Cite journal|vauthors=Frenkel EP, Mammen EF |title=Sticky platelet syndrome and thrombocythemia |journal=Hematol. Oncol. Clin. North Am. |volume=17 |issue=1 |pages=63–83 |date=February 2003 |pmid=12627663 |doi= 10.1016/S0889-8588(02)00096-5|url=}} 3. ^{{Cite journal|vauthors=Mears KA, Van Stavern GP |title=Bilateral Simultaneous Anterior Ischaemic Optic Neuropathy Associated with Sticky Platelet Syndrome |journal=Br J Ophthalmol |volume= 93|issue= 7|pages= 885–6, 913|date=July 2008 |pmid=18662911 |doi=10.1136/bjo.2008.142919 |url=http://bjo.bmj.com/cgi/pmidlookup?view=long&pmid=18662911}} 4. ^{{Cite journal|vauthors=Mammen EF, Barnhart MI, Selik NR, Gilroy J, Klepach GL |title="Sticky platelet syndrome": a congenital platelet abnormality predisposing to thrombosis? |journal=Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. |volume=115 |issue=3 |pages=361–5 |year=1988 |pmid=2465231 |doi= |url=}} 5. ^{{Cite journal |vauthors=Mühlfeld AS, Ketteler M, Schwamborn K, etal |title=Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients |journal=Am. J. Transplant. |volume=7 |issue=7 |pages=1865–8 |date=July 2007 |pmid=17532753 |doi=10.1111/j.1600-6143.2007.01835.x}} 6. ^{{Cite book|author=Bick, Rodger L |title=Hematological complications in obstetrics, pregnancy, and gynecology |publisher=Cambridge University Press |location=Cambridge, UK |year=2006 |pages=147 |isbn=978-0-521-83953-2 |oclc= |doi= |accessdate=}} 7. ^{{Cite book|author1=McKay, Robert |author2=David R. Gambling |title=Obstetric anesthesia and uncommon disorders |publisher=Cambridge University Press |location=Cambridge, UK |year=2008 |pages=308 |isbn=978-0-521-87082-5 |oclc= |doi= |accessdate=}} 8. ^{{Cite journal|vauthors=Chaturvedi S, Dzieczkowski JS |title=Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes |journal=Cerebrovasc. Dis. |volume=9 |issue=2 |pages=127–30 |year=1999 |pmid=9973658 |doi= 10.1159/000015911|url=http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=ced09127}} 9. ^{{cite journal | url = http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1C-47T2D4S-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fa06922a824e24db83382664b8659e30 | archive-url = https://archive.today/20120909181102/http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1C-47T2D4S-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fa06922a824e24db83382664b8659e30 | dead-url = yes | archive-date = 2012-09-09 | doi=10.1016/S0049-3848(02)00351-1 | volume=107 | issue=6 | title=Enhanced platelet aggregation with TRAP-6 and collagen in platelet aggregometry in patients with venous thromboembolism | journal=Thrombosis Research | pages=325–328| year=2002 | last1=Weber | first1=M. | last2=Gerdsen | first2=F. | last3=Gutensohn | first3=K. | last4=Schoder | first4=V. | last5=Eifrig | first5=B. | last6=Hossfeld | first6=D.K }} 10. ^{{cite journal | pmid = 10548069 | doi=10.1055/s-2007-994939 | volume=25 | issue=4 | title=Sticky platelet syndrome | year=1999 | journal=Semin. Thromb. Hemost. | pages=361–5 | author=Mammen EF}} }}{{Diseases of megakaryocytes}} 2 : Coagulopathies|Syndromes affecting blood |
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