| 释义 |
- References
- Further reading
{{Infobox_gene}}Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.[3]
}}References1. ^{{cite journal |vauthors=Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H | title = Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues | journal = Immunogenetics | volume = 49 | issue = 5 | pages = 369–75 |date=Jun 1999 | pmid = 10199912 | pmc = | doi =10.1007/s002510050509 }}
2. ^{{cite web | title = Entrez Gene: STK10 serine/threonine kinase 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6793| accessdate = }}
3. ^{{cite web | title = Entrez Gene: STK10 serine/threonine kinase 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6793| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Kuramochi S, Moriguchi T, Kuida K, etal |title=LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22679–84 |year= 1997 |pmid= 9278426 |doi=10.1074/jbc.272.36.22679 }}
- {{cite journal |vauthors=Tao L, Wadsworth S, Mercer J, etal |title=Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells. |journal=Biochem. J. |volume=363 |issue= Pt 1 |pages= 175–82 |year= 2002 |pmid= 11903060 |doi=10.1042/0264-6021:3630175 | pmc=1222464 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Walter SA, Cutler RE, Martinez R, etal |title=Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18221–8 |year= 2003 |pmid= 12639966 |doi= 10.1074/jbc.M212556200 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
- {{cite journal |vauthors=Bignell G, Smith R, Hunter C, etal |title=Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults. |journal=Genes Chromosomes Cancer |volume=45 |issue= 1 |pages= 42–6 |year= 2006 |pmid= 16175573 |doi= 10.1002/gcc.20265 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
- {{cite journal |vauthors=Wissing J, Jänsch L, Nimtz M, etal |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell. Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
{{refend}}{{PDB Gallery|geneid=6793}}{{Serine/threonine-specific protein kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-5-stub}} 1 : EC 2.7.11 |