Stoffels is a Dutch patronymic surname, meaning "son of Stoffel" (Christoffel). Notable people with the surname include:

• Carolus Stoffels (1893–1957), Dutch modern pentathlete
• Hendrickje Stoffels (1626–1663), Dutch artist's model, second partner of Rembrandt
• Jannik Stoffels (born 1997), German footballer
• Magdalena Stoffels (1993–2010), Namibian murder victim
• Marianne Stoffels, Belgian chess player
• Paul Stoffels (born 1962), Belgian physician
• Roel Stoffels (born 1987), Dutch footballer

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