| 词条 | Streptomyces tsukubaensis |
| 释义 |
| regnum = Bacteria | phylum = Actinobacteria | classis = Actinobacteria | ordo = Actinomycetales | familia = Streptomycetaceae | genus = Streptomyces | species = S. tsukubaensis | binomial = Streptomyces tsukubaensis | binomial_authority = }}Streptomyces tsukubaensis is a species of actinobacteria. It produces the immunosuppressive drug tacrolimus.[1][2] Tacrolimus was first isolated from S. tsukubaensis in 1984.[3] References1. ^{{cite journal | author=Pritchard D | title=Sourcing a chemical succession for cyclosporin from parasites and human pathogens | journal=Drug Discov Today | volume=10 | issue=10 | pages=688–91 | year=2005 | pmid=15896681 | doi=10.1016/S1359-6446(05)03395-7}} Supports source organism, but not team information 2. ^{{cite journal|doi=10.1186/s12934-015-0352-z|title=Roles of the crotonyl-CoA carboxylase/reductase homologues in acetate assimilation and biosynthesis of immunosuppressant FK506 in Streptomyces tsukubaensis|journal=Microbial Cell Factories|volume=14|year=2015|last1=Blažič|first1=Marko|last2=Kosec|first2=Gregor|last3=Baebler|first3=Špela|last4=Gruden|first4=Kristina|last5=Petković|first5=Hrvoje}} 3. ^{{cite journal |last1=Pirsch |first1=JD |last2=Miller |first2=J |last3=Deierhoi |first3=MH |last4=Vincenti |first4=F |last5=Filo |first5=RS |title=A comparison of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation. FK506 Kidney Transplant Study Group. |journal=Transplantation |date=15 April 1997 |volume=63 |issue=7 |pages=977-83 |pmid=9112351 |url=https://ia802605.us.archive.org/2/items/pubmed-PMC3967138/PMC3967138-pharmaceutics2030291.pdf |accessdate=28 August 2018}} Further reading{{cite journal|last1=Du|first1=W|last2=Huang|first2=D|last3=Xia|first3=M|last4=Wen|first4=J|last5=Huang|first5=M|title=Improved FK506 production by the precursors and product-tolerant mutant of Streptomyces tsukubaensis based on genome shuffling and dynamic fed-batch strategies.|journal=Journal of industrial microbiology & biotechnology|date=July 2014|volume=41|issue=7|pages=1131–43|pmid=24788378|doi=10.1007/s10295-014-1450-3}}{{Taxonbar|from=Q7623406}}{{Streptomyces-stub}} 1 : Streptomyces |
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