| 词条 | SUHW4 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 |
GeneThere are a total of 24 possible exons in any variant of the ZNF280D gene.[3] ZNF280D is oriented on the minus strand of Chromosome 15 and spans 288.396 kb.[4] Surrounding genes at the same locus include [https://www.ncbi.nlm.nih.gov/gene/374618 TEX9], [https://www.ncbi.nlm.nih.gov/gene/100873905 HMGB1P33], [https://www.ncbi.nlm.nih.gov/gene/55329 MNS1], [https://www.ncbi.nlm.nih.gov/gene/645877 LOC645877], and [https://www.ncbi.nlm.nih.gov/gene/145783 LOC145783].[5] mRNAAt least 24 spliced variants have been identified.[6] There are 7 probable alternative promoters. The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 12 cassette exons, overlapping exons with different boundaries, splicing versus retention of 5 introns.[6] The longest splice form contains 4428 bp.[7] ProteinComposition and DomainsThe ZNF280D protein is 979 amino acids in length.[8] The protein contains a domain of unknown function (DUF4195) spanning from amino acid 45 to amino acid 230.[8] DUF4195 (pfam13826) is a family that is found at the N-terminus of metazoan proteins that carry PHD-like zinc-finger domains; the function is unknown.[9] ZNF280D protein also contains five highly conserved Cys2His2-type zinc finger domains.[10] Zinc fingers have the ability to bind DNA, which supports the speculative role of ZNF280D as a transcription factor.[11] The protein has a weight of approximately 109.3 kdal.[12] Charge cluster analysis reveals a negative charge cluster near the N-terminus from amino acids 16-43.[12] Charge clusters are associated with functional domains of cellular transcription factors, providing further support for ZNF280D as a possible transcription factor.[13] InteractionsZNF280D has been experimentally determined to interact with CBX5 and CBX3 proteins.[14] These proteins both play a role in the formation of heterochromatin, which presents a possible functional role of ZNF280D as a transcriptional repressor.[15][16] SNPsThere are a number of SNPs that have been observed in the human population.[17] The image below lists some of the most frequently occurring. RegulationmRNA LevelA number of transcription factors are predicted to bind to the predicted promoter region.[18] Protein LevelZNF280D protein contains 66 serine, 17 threonine, and 6 tyrosine residues all of which are potential phosphorylation sites.[19] The glycine residue at position 2 is a probable candidate for N-terminal acetylation.[20] There are seven probable sumoylation sites.[21] ExpressionZNF280D is ubiquitously expressed at relatively low levels throughout almost all tissues in the human body.[22] In one study, the expression of ZNF280D was compared between endothelial progenitor cells in cord blood and peripheral blood. The results show that expression was significantly higher in cord blood. This supports a possible involvement of ZNF280D in embryonic development or cell differentiation.[23] EvolutionA number of orthologs and distant homologs have been identified for the human ZNF280D protein. There are also four paralogs to ZNF280D in the human genome.[24]
References1. ^{{cite journal | vauthors = Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 7 | issue = 4 | pages = 273–81 | date = August 2000 | pmid = 10997877 | pmc = | doi = 10.1093/dnares/7.4.271 }} 2. ^{{cite web | title = Entrez Gene: SUHW4 suppressor of hairy wing homolog 4 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54816| accessdate = }} 3. ^{{cite web|title=Genetic Testing Registry|url=https://www.ncbi.nlm.nih.gov/gtr/genes/54816/|publisher=NCBI|accessdate=7 May 2014}} 4. ^{{cite web|title=GeneCards|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=ZNF280D|accessdate=7 May 2014}} 5. ^{{cite web|title=ZNF280D zinc finger protein 280D [ Homo sapiens (human) ]|url=https://www.ncbi.nlm.nih.gov/gene/54816|publisher=NCBI|accessdate=9 May 2014}} 6. ^1 {{cite web|title=Homo sapiens complex locus ZNF280D, encoding zinc finger protein 280D and hypothetical LOC145783|url=https://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=znf280d&submit=Go|publisher=NCBI AceView|accessdate=7 May 2014}} 7. ^{{cite web|title=Homo sapiens zinc finger protein 280D, mRNA (cDNA clone MGC:168023 IMAGE:9020400), complete cds|url=https://www.ncbi.nlm.nih.gov/nuccore/BC136412.1|publisher=NCBI|accessdate=7 May 2014}} 8. ^1 {{cite web|title=Zinc finger protein 280D [Homo sapiens]|url=https://www.ncbi.nlm.nih.gov/protein/AAI36413.1|publisher=NCBI|accessdate=7 May 2014}} 9. ^{{cite web|title=pfam13836: DUF4195|url=https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=206007|publisher=NCBI|accessdate=7 May 2014}} 10. ^{{cite web|title=Q6N043 (Z280D_HUMAN)|url=https://www.uniprot.org/uniprot/Q6N043|publisher=UniProt|accessdate=7 May 2014}} 11. ^{{cite journal | vauthors = Klug A | title = Zinc finger peptides for the regulation of gene expression | journal = Journal of Molecular Biology | volume = 293 | issue = 2 | pages = 215–8 | date = October 1999 | pmid = 10529348 | doi = 10.1006/jmbi.1999.3007 }} 12. ^1 {{cite web|last=Brendel|first=Voker|title=SAPS Statistical Analysis of PS|url=http://seqtool.sdsc.edu/CGI/BW.cgi#!|publisher=SDSC Workbench|accessdate=7 May 2014}}{{dead link|date=April 2018 |bot=InternetArchiveBot |fix-attempted=yes }} 13. ^{{cite journal | vauthors = Brendel V, Karlin S | title = Association of charge clusters with functional domains of cellular transcription factors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 15 | pages = 5698–702 | date = August 1989 | pmid = 2569737 | pmc = 297697 | doi = 10.1073/pnas.86.15.5698 }} 14. ^{{cite web|title=STRING input ZNF280D (Homo sapiens)|url=http://string-db.org/newstring_cgi/show_network_section.pl|publisher=STRING|accessdate=10 May 2014}} 15. ^{{cite web|title=CBX5 [Homo sapiens]|url=https://www.ncbi.nlm.nih.gov/protein/CAG33699.1|publisher=NCBI|accessdate=10 May 2014}} 16. ^{{cite web|title=CBX3 [Homo sapiens]|url=https://www.ncbi.nlm.nih.gov/protein/NP_057671.2|publisher=NCBI|accessdate=10 May 2014}} 17. ^{{cite web|title=SNP linked to Gene ZNF280D(geneID:54816) Via Contig Annotation|url=https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?locusId=54816|publisher=NCBI|accessdate=10 May 2014}} 18. ^{{cite web|title=Genomatix|url=http://www.genomatix.de/|publisher=Genomatix|accessdate=7 May 2014}} 19. ^{{cite journal | vauthors = Blom N, Gammeltoft S, Brunak S | title = Sequence and structure-based prediction of eukaryotic protein phosphorylation sites | journal = Journal of Molecular Biology | volume = 294 | issue = 5 | pages = 1351–62 | date = December 1999 | pmid = 10600390 | doi = 10.1006/jmbi.1999.3310 }} 20. ^{{cite web|last=Kiemer|first=Lars|title=NetAcet: Prediction of N-terminal acetylation sites.|url=http://www.cbs.dtu.dk/services/NetAcet/|publisher=NetAcet|accessdate=7 May 2014}} 21. ^{{cite web|title=SUMOplot™ Analysis Program|url=http://www.abgent.com/sumoplot|accessdate=7 May 2014}} 22. ^{{cite web|title=GDS596 / 221213_s_at / ZNF280D|url=https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS596:221213_s_at|work=GEO Profile|publisher=NCBI|accessdate=7 May 2014}} 23. ^{{cite web|title=ZNF280D – Endothelial progenitor cells from cord blood and adult peripheral blood|url=https://www.ncbi.nlm.nih.gov/geoprofiles/88859397|publisher=NCBI|accessdate=9 May 2014}} 24. ^{{cite web|title=NCBI Basic Local Alignment Search Tool|url=http://blast.ncbi.nlm.nih.gov/Blast.cgi|publisher=NCBI|accessdate=10 May 2014}} 25. ^{{cite web|title=TimeTree|url=http://www.timetree.org/|publisher=TimeTree|accessdate=10 May 2014}} Further reading{{refbegin|33em}}
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