| 释义 |
- References
- Further reading
{{Infobox_gene}}Sulfotransferase 1A3/1A4 is an enzyme that in humans is encoded by the SULT1A3 gene.[1][2][3]Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1). Three alternatively spliced variants that encode the same protein have been described.[3] References1. ^{{cite journal | vauthors = Wood TC, Aksoy IA, Aksoy S, Weinshilboum RM | title = Human liver thermolabile phenol sulfotransferase: cDNA cloning, expression and characterization | journal = Biochem Biophys Res Commun | volume = 198 | issue = 3 | pages = 1119–27 |date=Mar 1994 | pmid = 8117269 | pmc = | doi = 10.1006/bbrc.1994.1159 }}
2. ^{{cite journal | vauthors = Aksoy IA, Callen DF, Apostolou S, Her C, Weinshilboum RM | title = Thermolabile phenol sulfotransferase gene (STM): localization to human chromosome 16p11.2 | journal = Genomics | volume = 23 | issue = 1 | pages = 275–7 |date=Feb 1995 | pmid = 7829089 | pmc = | doi = 10.1006/geno.1994.1494 }}
3. ^1 {{cite web | title = Entrez Gene: SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6818| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Weinshilboum RM, Otterness DM, Aksoy IA, etal |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3–14 |year= 1997 |pmid= 9034160 |doi= }}
- {{cite journal |vauthors=Glatt H, Engelke CE, Pabel U, etal |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112-113 |issue= |pages= 341–8 |year= 2000 |pmid= 10720750 |doi=10.1016/S0378-4274(99)00214-3 }}
- {{cite journal | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1–2 |pages= 141–70 |year= 2001 |pmid= 11154739 |doi=10.1016/S0009-2797(00)00202-7 }}
- {{cite journal |vauthors=Glatt H, Boeing H, Engelke CE, etal |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects |journal=Mutat. Res. |volume=482 |issue= 1–2 |pages= 27–40 |year= 2001 |pmid= 11535246 |doi= 10.1016/S0027-5107(01)00207-X}}
- {{cite journal | vauthors=Aksoy IA, Weinshilboum RM |title=Human thermolabile phenol sulfotransferase gene (STM): molecular cloning and structural characterization |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 2 |pages= 786–95 |year= 1995 |pmid= 7695637 |doi= 10.1006/bbrc.1995.1406 }}
- {{cite journal |vauthors=Jones AL, Hagen M, Coughtrie MW, etal |title=Human platelet phenolsulfotransferases: cDNA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form |journal=Biochem. Biophys. Res. Commun. |volume=208 |issue= 2 |pages= 855–62 |year= 1995 |pmid= 7695643 |doi= 10.1006/bbrc.1995.1414 }}
- {{cite journal |vauthors=Dooley TP, Probst P, Munroe PB, etal |title=Genomic organization and DNA sequence of the human catecholamine-sulfating phenol sulfotransferase gene (STM) |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 2 |pages= 1325–32 |year= 1995 |pmid= 7802665 |doi= 10.1006/bbrc.1994.2810 }}
- {{cite journal | vauthors=Bernier F, Leblanc G, Labrie F, Luu-The V |title=Structure of human estrogen and aryl sulfotransferase gene. Two mRNA species issued from a single gene |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 28200–5 |year= 1994 |pmid= 7961757 |doi= }}
- {{cite journal | vauthors=Veronese ME, Burgess W, Zhu X, McManus ME |title=Functional characterization of two human sulphotransferase cDNAs that encode monoamine- and phenol-sulphating forms of phenol sulphotransferase: substrate kinetics, thermal-stability and inhibitor-sensitivity studies |journal=Biochem. J. |volume=302 ( Pt 2) |issue= Pt 2|pages= 497–502 |year= 1994 |pmid= 8093002 |doi= | pmc=1137255 }}
- {{cite journal | vauthors=Bernier F, Lopez Solache I, Labrie F, Luu-The V |title=Cloning and expression of cDNA encoding human placental estrogen sulfotransferase |journal=Mol. Cell. Endocrinol. |volume=99 |issue= 1 |pages= R11–5 |year= 1994 |pmid= 8187949 |doi=10.1016/0303-7207(94)90159-7 }}
- {{cite journal |vauthors=Zhu X, Veronese ME, Bernard CC, etal |title=Identification of two human brain aryl sulfotransferase cDNAs |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 1 |pages= 120–7 |year= 1993 |pmid= 8363592 |doi=10.1006/bbrc.1993.2018 }}
- {{cite journal | vauthors=Her C, Raftogianis R, Weinshilboum RM |title=Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization |journal=Genomics |volume=33 |issue= 3 |pages= 409–20 |year= 1996 |pmid= 8661000 |doi= 10.1006/geno.1996.0216 }}
- {{cite journal | vauthors=Dooley TP, Huang Z |title=Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16 |journal=Biochem. Biophys. Res. Commun. |volume=228 |issue= 1 |pages= 134–40 |year= 1996 |pmid= 8912648 |doi= 10.1006/bbrc.1996.1628 }}
- {{cite journal |vauthors=Dajani R, Sharp S, Graham S, etal |title=Kinetic properties of human dopamine sulfotransferase (SULT1A3) expressed in prokaryotic and eukaryotic systems: comparison with the recombinant enzyme purified from Escherichia coli |journal=Protein Expr. Purif. |volume=16 |issue= 1 |pages= 11–8 |year= 1999 |pmid= 10336855 |doi= 10.1006/prep.1999.1030 }}
- {{cite journal |vauthors=Bidwell LM, McManus ME, Gaedigk A, etal |title=Crystal structure of human catecholamine sulfotransferase |journal=J. Mol. Biol. |volume=293 |issue= 3 |pages= 521–30 |year= 1999 |pmid= 10543947 |doi= 10.1006/jmbi.1999.3153 }}
- {{cite journal |vauthors=Dajani R, Cleasby A, Neu M, etal |title=X-ray crystal structure of human dopamine sulfotransferase, SULT1A3. Molecular modeling and quantitative structure-activity relationship analysis demonstrate a molecular basis for sulfotransferase substrate specificity |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37862–8 |year= 2000 |pmid= 10608851 |doi=10.1074/jbc.274.53.37862 }}
- {{cite journal | vauthors=Harris RM, Waring RH, Kirk CJ, Hughes PJ |title=Sulfation of "estrogenic" alkylphenols and 17beta-estradiol by human platelet phenol sulfotransferases |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 159–66 |year= 2000 |pmid= 10617600 |doi=10.1074/jbc.275.1.159 }}
{{refend}}{{PDB Gallery|geneid=6818}}{{protein-stub}} |