| 词条 | Sunepitron |
| 释义 |
| IUPAC_name = 1- | image = Sunepitron.png | tradename = | pregnancy_category = | legal_status = Uncontrolled | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 148408-65-5 | ATC_prefix = none | ATC_suffix = | PubChem = 9799246 | ChemSpiderID = 7975011 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 2GT50C8U60 | KEGG = D02569 | ChEMBL = 380369 | C=17 | H=23 | N=5 | O=2 | molecular_weight = 329.40 g/mol | smiles = O=C1N(C(=O)CC1)CC4CCC3N(CCN(c2ncccn2)C3)C4 }}Sunepitron (CP-93,393) is a combined 5-HT1A receptor agonist and α2-adrenergic receptor antagonist.[1][2] It was previously under development by Pfizer for the treatment of depression and anxiety.[3] It made it to phase III clinical trials before being discontinued.[2][3] SynthesisThe synthesis starts by conversion of the pyridine dicarboxylic acid (1) to its acid chloride; rxn with MeOH then affords the ester (2). Catalytic hydrogenation serves to reduce the pyridine ring to a piperidine of undefined stereochemistry (3). Alkylation of this intermediate with chloroacetonitrile affords (4). Treatment of that intermediate with Raney nickel reduces the cyano group to the corresponding primary amine; this product then undergoes an internal ester-amine interchange to yield the cyclized lactam (5). LAH serves to reduce the lactam to an amine; the ester on the other ring is reduced to a carbinol in the process, affording the aminoalcohol (7). The basic function is next alkylated with 2-chloropyrimidine (7). Rxn of the alcoholin (8) with MsCl leads to the mesylate; that group is next displaced by sodium azide (9); the azide group is next reduced to the primary amine. Resolution of this product as its mandelate salt then yields (10) as a single enantiomer. Rxn of that product with succinic anhydride converts the pendant amine to a succinimide, affording the anxiolytic agent sunepitron (1). See also
References1. ^{{cite journal | author = Goodnick PJ | title = Psychopharmacology of depression in the next millennium | journal = CNS Spectrums | volume = 4 | issue = 7 | pages = 21–35 |date=July 1999 | pmid = 18438295 | doi = | url = }} {{Antidepressants}}{{Anxiolytics}}{{Adrenergics}}{{Serotonergics}}2. ^1 {{cite book | author = Stahl, S. M. | title = Essential psychopharmacology: neuroscientific basis and practical application | publisher = Cambridge University Press | location = Cambridge, UK | year = 2000 | pages = | isbn = 0-521-64615-4 | oclc = | doi = | url = https://books.google.com/books?id=ICztBCFFRqEC&lpg=PA306&pg=PA265#v=onepage&q=&f=false}} 3. ^1 {{cite book |author1=Kaplan, Eliot F. |author2=Turkington, Carol | title = Making the antidepressant decision: how to choose the right treatment option for you and your loved ones | publisher = Contemporary Books | location = Chicago, Ill | year = 2001 | pages = | isbn = 0-7373-0417-0 | oclc = | doi = | url = https://books.google.com/books?id=qVtvcsUy2U8C&lpg=PA218&pg=PA218#v=onepage&q=&f=false}} 2 : Pyrimidines|Succinimides |
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