| 词条 | SymE-SymR toxin-antitoxin system |
| 释义 |
| Name = SymR | image = SymR_SScons.png | width = | caption = Conserved secondary structure of SymR RNA. | Symbol = SymR | AltSymbols = | Rfam = RF01809 | RNA_type = Antisense RNA | Tax_domain = E. coli }}{{Infobox protein family | Symbol = SymE_toxin | Name = SymE Toxin of Type I toxin-antitoxin system | image = | width = | caption = | Pfam = PF13957 | Pfam_clan = | InterPro = | SMART = | PROSITE = | MEROPS = | SCOP = | TCDB = | OPM family = | OPM protein = | CAZy = | CDD = }} The SymE-SymR toxin-antitoxin system consists of a small hydrophobic toxin named SymE and a non-coding RNA called SymR which inhibits its translation.[1] It is a type I toxin-antitoxin system, and is under regulation by the antitoxin, SymR.[2] Discovery of the systemSymR was originally labelled RyjC and is a 77nt RNA with a σ70 promoter. RyjC was found to overlap the yjiW open reading frame on the opposite strand by 6nt, and was characterised as an antisense RNA which bound the 5' untranslated region of yjiW.[3] Further study led to the renaming of both yjiW and RyjC to SymE (SOS-induced yjiW gene with similarity to MazE) and SymR (symbiotic RNA) respectively.[1] Mechanism of toxicitySymR blocks translation of SymE by antisense binding. SymE exhibits its toxicity by repressing global translation within the cell, cleaving mRNA in a similar manner to MazF, another toxin.[4] Quantitative Northern blot experiments showed that SymR RNA is present in cells at 10 times the concentration of SymE mRNA (0.02 fmol μg−1 and 0.2 fmol μg−1).[1] Following DNA damage, the SOS response represses transcription of SymR RNA, allowing SymE toxin to degrade potentially damaged mRNA until the DNA has been repaired.[1] See also
References1. ^1 2 3 {{cite journal |vauthors=Kawano M, Aravind L, Storz G |title=An antisense RNA controls synthesis of an SOS-induced toxin evolved from an antitoxin |journal=Mol. Microbiol. |volume=64 |issue=3 |pages=738–54 |date=May 2007 |pmid=17462020 |pmc=1891008 |doi=10.1111/j.1365-2958.2007.05688.x }} 2. ^{{Cite journal|title = Divergently overlapping cis-encoded antisense RNA regulating toxin-antitoxin systems from E. coli: hok/sok, ldr/rdl, symE/symR.|last = Kawano|first = M|date = December 2012|journal = RNA Biology|doi = 10.4161/rna.22757|pmid = 23131729|volume=9|pages=1520–7}} 3. ^{{cite journal |vauthors=Kawano M, Reynolds AA, Miranda-Rios J, Storz G |title=Detection of 5'- and 3'-UTR-derived small RNAs and cis-encoded antisense RNAs in Escherichia coli |journal=Nucleic Acids Res. |volume=33 |issue=3 |pages=1040–50 |year=2005 |pmid=15718303 |pmc=549416 |doi=10.1093/nar/gki256 |url=http://nar.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=15718303 |accessdate=2010-08-26}} 4. ^{{cite journal |vauthors=Gerdes K, Wagner EG |title=RNA antitoxins |journal=Curr. Opin. Microbiol. |volume=10 |issue=2 |pages=117–24 |date=April 2007 |pmid=17376733 |doi=10.1016/j.mib.2007.03.003 |url=http://linkinghub.elsevier.com/retrieve/pii/S1369-5274(07)00020-3 |accessdate=2010-08-26}} Further reading{{refbegin}}
External links
2 : Antisense RNA|RNA antitoxins |
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