“Syntaxin 3”的意思、由来-开放百科全书

Function

The protein encoded by this gene is a member of the syntaxin family of cellular receptors for transport vesicles which participate in exocytosis in neutrophils.^[2] STX3 has an important role in the growth of neurites and serves as a direct target for omega-6 arachidonic acid.^[4]

Mutations in Syntaxin 3 cause {{SWL|type=genetic_defect_results_in_disease|target=Microvillus inclusion disease|label=Microvillus inclusion disease}}.^[5]

Interactions

Syntaxin 3 has been shown to interact with SNAP-25,^[6]^[7]^[8] SNAP23^[7]^[8]^[9]^[10] and SNAP29.^[8]

References

1. ^{{cite journal | vauthors = Ibaraki K, Horikawa HP, Morita T, Mori H, Sakimura K, Mishina M, Saisu H, Abe T | title = Identification of four different forms of syntaxin 3 | journal = Biochem. Biophys. Res. Commun. | volume = 211 | issue = 3 | pages = 997–1005 | date = June 1995 | pmid = 7598732 | doi = 10.1006/bbrc.1995.1910 }}
2. ^¹{{cite journal | vauthors = Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F | title = Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1 | journal = J. Leukoc. Biol. | volume = 65 | issue = 3 | pages = 397–406 | date = March 1999 | pmid = 10080545 | doi = | url = http://www.jleukbio.org/cgi/content/abstract/65/3/397 }}
3. ^{{cite web | title = Entrez Gene: STX3 syntaxin 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6809| accessdate = }}
4. ^{{cite journal | vauthors = Darios F, Davletov B | title = Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3 | journal = Nature | volume = 440 | issue = 7085 | pages = 813–7 | date = April 2006 | pmid = 16598260 | doi = 10.1038/nature04598 | bibcode = 2006Natur.440..813D }}
5. ^{{cite journal | vauthors = Wiegerinck CL, Janecke AR, Schneeberger K, Vogel GF, van Haaften-Visser DY, Escher JC, Adam R, Thöni CE, Pfaller K, Jordan AJ, Weis CA, Nijman IJ, Monroe GR, van Hasselt PM, Cutz E, Klumperman J, Clevers H, Nieuwenhuis EE, Houwen RH, van Haaften G, Hess MW, Huber LA, Stapelbroek JM, Müller T, Middendorp S | title = Loss of syntaxin 3 causes variant microvillus inclusion disease | journal = Gastroenterology | volume = 147 | issue = 1 | pages = 65–68.e10 | year = 2014 | pmid = 24726755 | doi = 10.1053/j.gastro.2014.04.002 }}
6. ^{{cite journal | vauthors = Hata Y, Südhof TC | title = A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic | journal = J. Biol. Chem. | volume = 270 | issue = 22 | pages = 13022–8 | date = Jun 1995 | pmid = 7768895 | doi = 10.1074/jbc.270.22.13022 }}
7. ^¹{{cite journal | vauthors = Ravichandran V, Chawla A, Roche PA | title = Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues | journal = J. Biol. Chem. | volume = 271 | issue = 23 | pages = 13300–3 | date = Jun 1996 | pmid = 8663154 | doi = 10.1074/jbc.271.23.13300 }}
8. ^¹²{{cite journal | vauthors = Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH | title = Three novel proteins of the syntaxin/SNAP-25 family | journal = J. Biol. Chem. | volume = 273 | issue = 51 | pages = 34171–9 | date = Dec 1998 | pmid = 9852078 | doi = 10.1074/jbc.273.51.34171 }}
9. ^{{cite journal | vauthors = Imai A, Nashida T, Yoshie S, Shimomura H | title = Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane | journal = Arch. Oral Biol. | volume = 48 | issue = 8 | pages = 597–604 | date = Aug 2003 | pmid = 12828989 | doi = 10.1016/S0003-9969(03)00116-X }}
10. ^{{cite journal | vauthors = Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M | title = Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c | journal = Biochem. Biophys. Res. Commun. | volume = 234 | issue = 1 | pages = 257–62 | date = May 1997 | pmid = 9168999 | doi = 10.1006/bbrc.1997.6560 }}

Further reading

{{cite journal | vauthors = Ibaraki K, Horikawa HP, Morita T, Mori H, Sakimura K, Mishina M, Saisu H, Abe T | title = Identification of four different forms of syntaxin 3 | journal = Biochem. Biophys. Res. Commun. | volume = 211 | issue = 3 | pages = 997–1005 | year = 1995 | pmid = 7598732 | doi = 10.1006/bbrc.1995.1910 }}

{{cite journal | vauthors = Hata Y, Südhof TC | title = A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic | journal = J. Biol. Chem. | volume = 270 | issue = 22 | pages = 13022–8 | year = 1995 | pmid = 7768895 | doi = 10.1074/jbc.270.22.13022 }}

{{cite journal | vauthors = Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC | title = Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins | journal = Nature | volume = 375 | issue = 6532 | pages = 594–9 | year = 1995 | pmid = 7791877 | doi = 10.1038/375594a0 | bibcode = 1995Natur.375..594L }}

{{cite journal | vauthors = Morgans CW, Brandstätter JH, Kellerman J, Betz H, Wässle H | title = A SNARE complex containing syntaxin 3 is present in ribbon synapses of the retina | journal = J. Neurosci. | volume = 16 | issue = 21 | pages = 6713–21 | year = 1996 | pmid = 8824312 | doi = }}

{{cite journal | vauthors = Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW, James DE | title = Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4 | journal = J. Biol. Chem. | volume = 272 | issue = 10 | pages = 6179–86 | year = 1997 | pmid = 9045631 | doi = 10.1074/jbc.272.10.6179 }}

{{cite journal | vauthors = Delgrossi MH, Breuza L, Mirre C, Chavrier P, Le Bivic A | title = Human syntaxin 3 is localized apically in human intestinal cells | journal = J. Cell Sci. | volume = 110 ( Pt 18) | issue = 18 | pages = 2207–14 | year = 1997 | pmid = 9378770 | doi = }}

{{cite journal | vauthors = Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D | title = A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells | journal = Mol. Biol. Cell | volume = 9 | issue = 6 | pages = 1437–48 | year = 1998 | pmid = 9614185 | pmc = 25366 | doi = 10.1091/mbc.9.6.1437 }}

{{cite journal | vauthors = Riento K, Galli T, Jansson S, Ehnholm C, Lehtonen E, Olkkonen VM | title = Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells | journal = J. Cell Sci. | volume = 111 ( Pt 17) | issue = 17 | pages = 2681–8 | year = 1998 | pmid = 9701566 | doi = }}

{{cite journal | vauthors = Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH | title = Three novel proteins of the syntaxin/SNAP-25 family | journal = J. Biol. Chem. | volume = 273 | issue = 51 | pages = 34171–9 | year = 1998 | pmid = 9852078 | doi = 10.1074/jbc.273.51.34171 }}

{{cite journal | vauthors = Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F | title = Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1 | journal = J. Leukoc. Biol. | volume = 65 | issue = 3 | pages = 397–406 | year = 1999 | pmid = 10080545 | doi = }}

{{cite journal | vauthors = Fasshauer D, Antonin W, Margittai M, Pabst S, Jahn R | title = Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties | journal = J. Biol. Chem. | volume = 274 | issue = 22 | pages = 15440–6 | year = 1999 | pmid = 10336434 | doi = 10.1074/jbc.274.22.15440 | url = http://pubman.mpdl.mpg.de/pubman/item/escidoc:600498/component/escidoc:2224261/600498.pdf }}

{{cite journal | vauthors = Thomas DM, Ferguson GD, Herschman HR, Elferink LA | title = Functional and biochemical analysis of the C2 domains of synaptotagmin IV | journal = Mol. Biol. Cell | volume = 10 | issue = 7 | pages = 2285–95 | year = 1999 | pmid = 10397765 | pmc = 25443 | doi = 10.1091/mbc.10.7.2285 }}

{{cite journal | vauthors = Riento K, Kauppi M, Keranen S, Olkkonen VM | title = Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells | journal = J. Biol. Chem. | volume = 275 | issue = 18 | pages = 13476–83 | year = 2000 | pmid = 10788461 | doi = 10.1074/jbc.275.18.13476 }}

{{cite journal | vauthors = Kauppi M, Wohlfahrt G, Olkkonen VM | title = Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3 | journal = J. Biol. Chem. | volume = 277 | issue = 46 | pages = 43973–9 | year = 2002 | pmid = 12198139 | doi = 10.1074/jbc.M208315200 }}

{{cite journal | vauthors = Imai A, Nashida T, Yoshie S, Shimomura H | title = Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane | journal = Arch. Oral Biol. | volume = 48 | issue = 8 | pages = 597–604 | year = 2003 | pmid = 12828989 | doi = 10.1016/S0003-9969(03)00116-X }}

{{cite journal | vauthors = Bandyopadhyay BC, Swaim WD, Liu X, Redman RS, Patterson RL, Ambudkar IS | title = Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx | journal = J. Biol. Chem. | volume = 280 | issue = 13 | pages = 12908–16 | year = 2005 | pmid = 15623527 | doi = 10.1074/jbc.M410013200 }}

{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R }}

{{cite journal | vauthors = Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T | title = Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity | journal = Mol. Biol. Cell | volume = 17 | issue = 2 | pages = 977–89 | year = 2006 | pmid = 16339081 | pmc = 1356605 | doi = 10.1091/mbc.E05-05-0462 }}