“SYTL2”的意思、由来-开放百科全书

Function

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed.^[1]

References

1. ^¹{{cite web | title = Entrez Gene: SYTL2 synaptotagmin-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54843| accessdate = }}
2. ^{{cite journal | vauthors = Fukuda M | title = Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15390–6 | date = April 2003 | pmid = 12590134 | doi = 10.1074/jbc.M213090200 }}
3. ^{{cite journal | vauthors = Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC | title = A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport | journal = The Journal of Biological Chemistry | volume = 277 | issue = 28 | pages = 25423–30 | date = July 2002 | pmid = 11980908 | doi = 10.1074/jbc.M202574200 }}
4. ^{{cite journal | vauthors = Kuroda TS, Fukuda M, Ariga H, Mikoshiba K | title = The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain | journal = The Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 9212–8 | date = March 2002 | pmid = 11773082 | doi = 10.1074/jbc.M112414200 }}

Further reading

{{cite journal | vauthors = Nalefski EA, Falke JJ | title = The C2 domain calcium-binding motif: structural and functional diversity | journal = Protein Science | volume = 5 | issue = 12 | pages = 2375–90 | date = December 1996 | pmid = 8976547 | pmc = 2143302 | doi = 10.1002/pro.5560051201 }}

{{cite journal | vauthors = Duncan RR, Shipston MJ, Chow RH | title = Double C2 protein. A review | journal = Biochimie | volume = 82 | issue = 5 | pages = 421–6 | date = May 2000 | pmid = 10865129 | doi = 10.1016/S0300-9084(00)00214-5 }}

{{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}

{{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}

{{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3491–6 | date = March 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 }}

{{cite journal | vauthors = Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 7 | issue = 4 | pages = 273–81 | date = August 2000 | pmid = 10997877 | doi = 10.1093/dnares/7.4.271 }}

{{cite journal | vauthors = Fukuda M, Mikoshiba K | title = Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins | journal = Biochemical and Biophysical Research Communications | volume = 281 | issue = 5 | pages = 1226–33 | date = March 2001 | pmid = 11243866 | doi = 10.1006/bbrc.2001.4512 }}

{{cite journal | vauthors = Fukuda M, Saegusa C, Mikoshiba K | title = Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain | journal = Biochemical and Biophysical Research Communications | volume = 283 | issue = 2 | pages = 513–9 | date = May 2001 | pmid = 11327731 | doi = 10.1006/bbrc.2001.4803 }}

{{cite journal | vauthors = Craxton M | title = Genomic analysis of synaptotagmin genes | journal = Genomics | volume = 77 | issue = 1-2 | pages = 43–9 | date = September 2001 | pmid = 11543631 | doi = 10.1006/geno.2001.6619 }}

{{cite journal | vauthors = Kuroda TS, Fukuda M, Ariga H, Mikoshiba K | title = The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain | journal = The Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 9212–8 | date = March 2002 | pmid = 11773082 | doi = 10.1074/jbc.M112414200 }}

{{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 26 | pages = 16899–903 | date = December 2002 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}

{{cite journal | vauthors = Fukuda M | title = Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15390–6 | date = April 2003 | pmid = 12590134 | doi = 10.1074/jbc.M213090200 }}

{{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = July 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}

{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

{{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}

{{cite journal | vauthors = Yu M, Kasai K, Nagashima K, Torii S, Yokota-Hashimoto H, Okamoto K, Takeuchi T, Gomi H, Izumi T | title = Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain | journal = Molecular Biology of the Cell | volume = 18 | issue = 2 | pages = 688–96 | date = February 2007 | pmid = 17182843 | pmc = 1783794 | doi = 10.1091/mbc.E06-10-0914 }}

Function

Interactions

References

Further reading