| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Trace amine associated receptor 6, also known as TAAR6, is a protein which in humans is encoded by the TAAR6 gene.[1][2] Function TAAR6 belongs to the trace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.[3][4] References1. ^{{cite journal | vauthors = Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C | title = Trace amines: identification of a family of mammalian G protein-coupled receptors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 16 | pages = 8966–71 |date=July 2001 | pmid = 11459929 | pmc = 55357 | doi = 10.1073/pnas.151105198 | url = }}
2. ^{{cite journal | vauthors = Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC | title = Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors | journal = Genomics | volume = 85 | issue = 3 | pages = 372–85 |date=March 2005 | pmid = 15718104 | doi = 10.1016/j.ygeno.2004.11.010 | url = }}
3. ^{{cite journal | vauthors = Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV | title = Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia | journal = Am. J. Hum. Genet. | volume = 75 | issue = 4 | pages = 624–38 |date=October 2004 | pmid = 15329799 | pmc = 1182049 | doi = 10.1086/424887 | url = }}
4. ^{{cite web | title = Entrez Gene: TAAR6 trace amine associated receptor 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=319100| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Cao Q, Martinez M, Zhang J, etal |title=Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. |journal=Genomics |volume=43 |issue= 1 |pages= 1–8 |year= 1997 |pmid= 9226366 |doi= 10.1006/geno.1997.4815 }}
- {{cite journal |vauthors=Kaufmann CA, Suarez B, Malaspina D, etal |title=NIMH Genetics Initiative Millennium Schizophrenia Consortium: linkage analysis of African-American pedigrees. |journal=Am. J. Med. Genet. |volume=81 |issue= 4 |pages= 282–9 |year= 1998 |pmid= 9674972 |doi=10.1002/(SICI)1096-8628(19980710)81:4<282::AID-AJMG2>3.0.CO;2-W }}
- {{cite journal |vauthors=Borowsky B, Adham N, Jones KA, etal |title=Trace amines: identification of a family of mammalian G protein-coupled receptors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 16 |pages= 8966–71 |year= 2001 |pmid= 11459929 |doi= 10.1073/pnas.151105198 | pmc=55357 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
- {{cite journal |vauthors=Duan J, Martinez M, Sanders AR, etal |title=Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. |journal=Am. J. Hum. Genet. |volume=75 |issue= 4 |pages= 624–38 |year= 2004 |pmid= 15329799 |doi= 10.1086/424887 | pmc=1182049 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Lindemann L, Ebeling M, Kratochwil NA, etal |title=Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. |journal=Genomics |volume=85 |issue= 3 |pages= 372–85 |year= 2005 |pmid= 15718104 |doi= 10.1016/j.ygeno.2004.11.010 }}
- {{cite journal |vauthors=Amann D, Avidan N, Kanyas K, etal |title=The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23. |journal=Mol. Psychiatry |volume=11 |issue= 2 |pages= 119–21 |year= 2006 |pmid= 16189505 |doi= 10.1038/sj.mp.4001752 }}
{{refend}}{{NLM content}}{{TAAR ligands}}{{G protein-coupled receptors}}{{transmembranereceptor-stub}} 1 : G protein-coupled receptors |