| 词条 | Tabernanthine |
| 释义 |
| IUPAC_name = (1R,15R,17S,18S)-17-ethyl-6-methoxy-3,13-diazapentacyclo[13.3.1.0²,¹⁰.0⁴,⁹.0¹³,¹⁸]nonadeca-2(10),4(9),5,7-tetraene | image = Tabernanthine.svg | alt = Skeletal formula of tabernanthine | width = 240 | image2 = Tabernanthine molecule ball.png | alt2 = Ball-and-stick model of the tabernanthine molecule | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 83-94-3 | ATC_prefix = none | ATC_suffix = | PubChem = 6326116 | ChemSpiderID = 4885254 | UNII = TV52I1S16D | C=20 | H=26 | N=2 | O=1 | molecular_weight = 310.43 g/mol | smiles = CCC1CC2CC3C1N(C2)CCC4=C3NC5=C4C=CC(=C5)OC | StdInChI = 1S/C20H26N2O/c1-3-13-8-12-9-17-19-16(6-7-22(11-12)20(13)17)15-5-4-14(23-2)10-18(15)21-19/h4-5,10,12-13,17,20-21H,3,6-9,11H2,1-2H3/t12-,13+,17+,20+/m1/s1 | StdInChIKey = UCIDWKVIQZIKEK-CFDPKNGZSA-N }}Tabernanthine is an alkaloid found in Tabernanthe iboga.[1] It has been used in laboratory experiments to study how addiction affects the brain.[2] Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.[3] See also
References1. ^{{cite journal | title = The Alkaloids of Tabernanthe iboga. Part IV.1 The Structures of Ibogamine, Ibogaine, Tabernanthine and Voacangine - Journal of the American Chemical Society (ACS Publications) | journal = Journal of the American Chemical Society| volume = 80| pages = 126–136| doi = 10.1021/ja01534a036 |year = 1958|last1 = Bartlett|first1 = M. F.| last2 = Dickel| first2 = D. F.| last3 = Taylor| first3 = W. I.}} {{Antiaddictives}}{{Ionotropic glutamate receptor modulators}}{{Opioid receptor modulators}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Levi MS, Borne RF |title=A review of chemical agents in the pharmacotherapy of addiction |journal=Curr. Med. Chem. |volume=9 |issue=20 |pages=1807–18 |date=October 2002 |pmid=12369879 |doi= 10.2174/0929867023368980|url=}} 3. ^{{cite journal |vauthors=Glick SD, Kuehne ME, Raucci J, Wilson TE, Larson D, Keller RW Jr, Carlson JN |title=Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum.|journal=Brain Res. |volume=657 |issue=1–2 |pages=14–22 |date=September 1994 |pmid=7820611 |doi= 10.1016/0006-8993(94)90948-2|url=}} 3 : Alkaloids|Alkaloids found in Iboga|NMDA receptor antagonists |
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