请输入您要查询的百科知识：

　

词条 TACC1
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Transforming acidic coiled-coil-containing protein 1 is a protein that in humans is encoded by the TACC1 gene.[1]

Function

The function of this gene has not yet been determined; however, it is speculated that it may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers.[1]

Interactions

TACC1 has been shown to interact with:

{{div col|colwidth=20em}}
  • Aurora A kinase,[2][3]
  • Aurora B kinase,[2]
  • BARD1,[4]
  • CKAP5,[3][5]
  • LSM7,[3][10]
  • SNRPG,[6] and
  • TDRD7.[3]
{{Div col end}}

References

1. ^1 {{cite web | title = Entrez Gene: TACC1 transforming, acidic coiled-coil containing protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6867| accessdate = }}
2. ^1 {{cite journal | vauthors = Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D | title = Aurora B -TACC1 protein complex in cytokinesis | journal = Oncogene | volume = 23 | issue = 26 | pages = 4516–22 | date = Jun 2004 | pmid = 15064709 | doi = 10.1038/sj.onc.1207593 }}
3. ^1 2 3 {{cite journal | vauthors = Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D | title = TACC1-chTOG-Aurora A protein complex in breast cancer | journal = Oncogene | volume = 22 | issue = 50 | pages = 8102–16 | date = Nov 2003 | pmid = 14603251 | doi = 10.1038/sj.onc.1206972 }}
4. ^{{cite journal | vauthors = Ryser S, Dizin E, Jefford CE, Delaval B, Gagos S, Christodoulidou A, Krause KH, Birnbaum D, Irminger-Finger I | title = Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2 | journal = Cancer Res. | volume = 69 | issue = 3 | pages = 1125–34 | date = Feb 2009 | pmid = 19176389 | doi = 10.1158/0008-5472.CAN-08-2134 }}
5. ^{{cite journal | vauthors = Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH | title = Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells | journal = Biochem. J. | volume = 363 | issue = Pt 1 | pages = 195–200 | date = Apr 2002 | pmid = 11903063 | pmc = 1222467 | doi = 10.1042/0264-6021:3630195}}
6. ^1 {{cite journal | vauthors = Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D | title = Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators | journal = Oncogene | volume = 21 | issue = 36 | pages = 5619–30 | date = Aug 2002 | pmid = 12165861 | doi = 10.1038/sj.onc.1205658 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Lappin TR, Mullan RN, Stewart JP, Morgan NA, Thompson A, Maxwell AP | title = AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains | journal = Leuk. Lymphoma | volume = 43 | issue = 7 | pages = 1455–9 | year = 2003 | pmid = 12389629 | doi = 10.1080/1042819022386644 }}
  • {{cite journal | vauthors = Still IH, Vince P, Cowell JK | title = The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines | journal = Genomics | volume = 58 | issue = 2 | pages = 165–70 | year = 1999 | pmid = 10366448 | doi = 10.1006/geno.1999.5829 }}
  • {{cite journal | vauthors = Still IH, Hamilton M, Vince P, Wolfman A, Cowell JK | title = Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon | journal = Oncogene | volume = 18 | issue = 27 | pages = 4032–8 | year = 1999 | pmid = 10435627 | doi = 10.1038/sj.onc.1202801 }}
  • {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 6 | issue = 3 | pages = 197–205 | year = 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}
  • {{cite journal | vauthors = Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff JW | title = The TACC domain identifies a family of centrosomal proteins that can interact with microtubules | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 26 | pages = 14352–7 | year = 2001 | pmid = 11121038 | pmc = 18922 | doi = 10.1073/pnas.97.26.14352 }}
  • {{cite journal | vauthors = Lauffart B, Howell SJ, Tasch JE, Cowell JK, Still IH | title = Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells | journal = Biochem. J. | volume = 363 | issue = Pt 1 | pages = 195–200 | year = 2002 | pmid = 11903063 | pmc = 1222467 | doi = 10.1042/0264-6021:3630195 }}
  • {{cite journal | vauthors = Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC | title = Serological identification and expression analysis of gastric cancer-associated genes | journal = Br. J. Cancer | volume = 86 | issue = 11 | pages = 1824–30 | year = 2002 | pmid = 12087473 | pmc = 2375403 | doi = 10.1038/sj.bjc.6600321 }}
  • {{cite journal | vauthors = Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D | title = Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators | journal = Oncogene | volume = 21 | issue = 36 | pages = 5619–30 | year = 2002 | pmid = 12165861 | doi = 10.1038/sj.onc.1205658 }}
  • {{cite journal | vauthors = Line A, Slucka Z, Stengrevics A, Li G, Rees RC | title = Altered splicing pattern of TACC1 mRNA in gastric cancer | journal = Cancer Genet. Cytogenet. | volume = 139 | issue = 1 | pages = 78–83 | year = 2003 | pmid = 12547166 | doi = 10.1016/S0165-4608(02)00607-6 }}
  • {{cite journal | vauthors = Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D | title = TACC1-chTOG-Aurora A protein complex in breast cancer | journal = Oncogene | volume = 22 | issue = 50 | pages = 8102–16 | year = 2003 | pmid = 14603251 | doi = 10.1038/sj.onc.1206972 }}
  • {{cite journal | vauthors = Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH | title = The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases | journal = Oncogene | volume = 23 | issue = 14 | pages = 2559–63 | year = 2004 | pmid = 14767476 | doi = 10.1038/sj.onc.1207424 }}
  • {{cite journal | vauthors = Delaval B, Ferrand A, Conte N, Larroque C, Hernandez-Verdun D, Prigent C, Birnbaum D | title = Aurora B -TACC1 protein complex in cytokinesis | journal = Oncogene | volume = 23 | issue = 26 | pages = 4516–22 | year = 2004 | pmid = 15064709 | doi = 10.1038/sj.onc.1207593 }}
  • {{cite journal | vauthors = Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P | title = Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms | journal = BMC Evol. Biol. | volume = 4 | pages = 16 | year = 2004 | pmid = 15207008 | pmc = 441373 | doi = 10.1186/1471-2148-4-16 }}
  • {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
  • {{cite journal | vauthors = Lauffart B, Dimatteo A, Vaughan MM, Cincotta MA, Black JD, Still IH | title = Temporal and spatial expression of TACC1 in the mouse and human | journal = Dev. Dyn. | volume = 235 | issue = 6 | pages = 1638–47 | year = 2007 | pmid = 16496324 | doi = 10.1002/dvdy.20724 }}
  • {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
{{refend}}{{gene-8-stub}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/11 20:51:28