| 词条 | Talsupram |
| 释义 |
| IUPAC_name = 3-(3,3-dimethyl-1-phenyl-2-benzothiophen-1-yl)-N-methyl-propan-1-amine | image = Talsupram.svg | tradename = | pregnancy_category = | legal_status = Uncontrolled | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 21489-20-3 | ATC_prefix = none | ATC_suffix = | PubChem = 33014 | ChemSpiderID = 30557 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = C6Z73MW6CR | C=20 | H=25 | N=1 | S=1 | molecular_weight = 311.48 g/mol }}Talsupram (Lu 5-005 or Lu 5-003[1]) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.[2][3][4] Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.[5] See also
References1. ^[https://www.researchgate.net/profile/Kjell_Fuxe/publication/17418212_Effect_of_a_new_series_of_bicyclic_compounds_with_potential_thymoleptic_properties_on_the_reserpine-resistant_uptake_mechanism_of_central_and_peripheral_monoamine_neurones_in_vivo_and_in_vitro/links/00463532ebcbe053d5000000.pdf Br. J. Pharmac. (1969), 36, 18-28. Effect of a new series of bicyclic compounds with potential thymoleptic properties on the reserpine-resistant uptake mechanism of central and peripheral monoamine neurones in vivo and in vitro A. CARLSSON, K. FUXE, B. HAMBERGER AND T. MALMFORS] {{Antidepressants}}{{Monoamine reuptake inhibitors}}{{nervous-system-drug-stub}}2. ^{{cite journal | vauthors = Pawłowski L, Mazela H | title = Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice | journal = Psychopharmacology | volume = 88 | issue = 2 | pages = 240–6 | year = 1986 | pmid = 3006113 | doi = 10.1007/BF00652248| url = }} 3. ^{{cite journal |vauthors=McConathy J, Owens MJ, Kilts CD, etal | title = Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter | journal = Nuclear Medicine and Biology | volume = 31 | issue = 6 | pages = 705–18 |date=August 2004 | pmid = 15246361 | doi = 10.1016/j.nucmedbio.2003.05.001 | url = http://linkinghub.elsevier.com/retrieve/pii/S096980510400054X}} 4. ^{{cite journal | vauthors = Kelliher P, Kelly JP, Leonard BE, Sánchez C | title = Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test | journal = Psychoneuroendocrinology | volume = 28 | issue = 3 | pages = 332–47 |date=April 2003 | pmid = 12573300 | doi = 10.1016/S0306-4530(02)00026-4| url = http://linkinghub.elsevier.com/retrieve/pii/S0306453002000264}} 5. ^http://www.healyprozac.com/Book/Introduction.doc 3 : Antidepressants|Norepinephrine reuptake inhibitors|Benzo(c)thiophenes |
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