“TANK (gene)”的意思、由来-开放百科全书

Function

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

TANK (gene) has been shown to interact with TANK-binding kinase 1,^[4]^[5] IKBKE,^[6] TRAF2,^[1]^[4]^[5]^[6] IKBKG^[7] and TRAF3.^[1]^[4]

References

1. ^¹²{{cite journal | vauthors = Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV | title = I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 16 | pages = 8241–6 | date = August 1996 | pmid = 8710854 | pmc = 38654 | doi = 10.1073/pnas.93.16.8241 }}
2. ^{{cite journal | vauthors = Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G | title = Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 20 | pages = 11085–90 | date = October 1996 | pmid = 8855313 | pmc = 38288 | doi = 10.1073/pnas.93.20.11085 }}
3. ^¹{{cite web | title = Entrez Gene: TANK TRAF family member-associated NFKB activator| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10010| accessdate = }}
4. ^¹²{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = February 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
5. ^¹{{cite journal | vauthors = Pomerantz JL, Baltimore D | title = NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase | journal = The EMBO Journal | volume = 18 | issue = 23 | pages = 6694–704 | date = December 1999 | pmid = 10581243 | pmc = 1171732 | doi = 10.1093/emboj/18.23.6694 }}
6. ^¹{{cite journal | vauthors = Nomura F, Kawai T, Nakanishi K, Akira S | title = NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation | journal = Genes to Cells | volume = 5 | issue = 3 | pages = 191–202 | date = March 2000 | pmid = 10759890 | doi = 10.1046/j.1365-2443.2000.00315.x }}
7. ^{{cite journal | vauthors = Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U | title = Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37029–36 | date = October 2002 | pmid = 12133833 | doi = 10.1074/jbc.M205069200 }}

Further reading

{{cite journal | vauthors = Chin AI, Shu J, Shan Shi C, Yao Z, Kehrl JH, Cheng G | title = TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway | journal = Molecular and Cellular Biology | volume = 19 | issue = 10 | pages = 6665–72 | date = October 1999 | pmid = 10490605 | pmc = 84649 | doi = }}

{{cite journal | vauthors = Pomerantz JL, Baltimore D | title = NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase | journal = The EMBO Journal | volume = 18 | issue = 23 | pages = 6694–704 | date = December 1999 | pmid = 10581243 | pmc = 1171732 | doi = 10.1093/emboj/18.23.6694 }}

{{cite journal | vauthors = Nomura F, Kawai T, Nakanishi K, Akira S | title = NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation | journal = Genes to Cells | volume = 5 | issue = 3 | pages = 191–202 | date = March 2000 | pmid = 10759890 | doi = 10.1046/j.1365-2443.2000.00315.x }}

{{cite journal | vauthors = Zapata JM, Pawlowski K, Haas E, Ware CF, Godzik A, Reed JC | title = A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 24242–52 | date = June 2001 | pmid = 11279055 | doi = 10.1074/jbc.M100354200 }}

{{cite journal | vauthors = Li C, Ni CZ, Havert ML, Cabezas E, He J, Kaiser D, Reed JC, Satterthwait AC, Cheng G, Ely KR | title = Downstream regulator TANK binds to the CD40 recognition site on TRAF3 | journal = Structure | volume = 10 | issue = 3 | pages = 403–11 | date = March 2002 | pmid = 12005438 | doi = 10.1016/S0969-2126(02)00733-5 }}

{{cite journal | vauthors = Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U | title = Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37029–36 | date = October 2002 | pmid = 12133833 | doi = 10.1074/jbc.M205069200 }}

{{cite journal | vauthors = Ishida R, Ezura Y, Emi M, Kajita M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Ito H, Orimo H | title = Association of a promoter haplotype (-1542G/-525C) in the tumor necrosis factor receptor associated factor-interacting protein gene with low bone mineral density in Japanese women | journal = Bone | volume = 33 | issue = 2 | pages = 237–41 | date = August 2003 | pmid = 14499357 | doi = 10.1016/S8756-3282(03)00226-6 }}

{{cite journal | vauthors = Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR | title = Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 50523–9 | date = December 2003 | pmid = 14517219 | doi = 10.1074/jbc.M309381200 }}

{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = February 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}

{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

{{cite journal | vauthors = Bonif M, Meuwis MA, Close P, Benoit V, Heyninck K, Chapelle JP, Bours V, Merville MP, Piette J, Beyaert R, Chariot A | title = TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation | journal = The Biochemical Journal | volume = 394 | issue = Pt 3 | pages = 593–603 | date = March 2006 | pmid = 16336209 | pmc = 1383709 | doi = 10.1042/BJ20051659 }}

{{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}

{{cite journal | vauthors = Guo B, Cheng G | title = Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK | journal = The Journal of Biological Chemistry | volume = 282 | issue = 16 | pages = 11817–26 | date = April 2007 | pmid = 17327220 | doi = 10.1074/jbc.M700017200 }}

{{cite journal | vauthors = Ryzhakov G, Randow F | title = SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK | journal = The EMBO Journal | volume = 26 | issue = 13 | pages = 3180–90 | date = July 2007 | pmid = 17568778 | pmc = 1914091 | doi = 10.1038/sj.emboj.7601743 }}

{{cite journal | vauthors = Gatot JS, Gioia R, Chau TL, Patrascu F, Warnier M, Close P, Chapelle JP, Muraille E, Brown K, Siebenlist U, Piette J, Dejardin E, Chariot A | title = Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF | journal = The Journal of Biological Chemistry | volume = 282 | issue = 43 | pages = 31131–46 | date = October 2007 | pmid = 17823124 | doi = 10.1074/jbc.M701690200 }}

Function

Interactions

References

Further reading

External links