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词条 Tazomeline
释义

  1. See also

  2. References

{{Drugbox
| IUPAC_name = 5-[4-(hexylsulfanyl)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine
| image = Tazomeline.png
| tradename =
| pregnancy_category =
| legal_status =
| routes_of_administration =
| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number = 131987-54-7
| ATC_prefix = None
| ATC_suffix =
| PubChem = 131460
| ChemSpiderID = 116193
| ChEMBL = 131819
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = QDP6S14W5W
| C=14 | H=23 | N=3 | S=2
| molecular_weight = 297.48 g/mol
| smiles = n2snc(/C1=C/CCN(C)C1)c2SCCCCCC
}}Tazomeline (LY-287,041) is a drug which acts as a non-selective muscarinic acetylcholine receptor agonist.[1][2] It was in clinical trials for the treatment of cognitive dysfunction such as that seen in Alzheimer's disease and schizophrenia, but development was apparently scrapped for unknown reasons.[1][2][3]

See also

  • Alvameline
  • Milameline
  • Sabcomeline
  • Xanomeline

References

1. ^{{cite journal |vauthors=Langmead CJ, Watson J, Reavill C | title = Muscarinic acetylcholine receptors as CNS drug targets | journal = Pharmacology & Therapeutics | volume = 117 | issue = 2 | pages = 232–43 |date=February 2008 | pmid = 18082893 | doi = 10.1016/j.pharmthera.2007.09.009 | url = http://linkinghub.elsevier.com/retrieve/pii/S0163-7258(07)00207-0}}
2. ^{{cite journal | author = Amos D Korczyn | title = Muscarinic M1 Agonists in the Treatment of Alzheimer's Disease | journal = Expert Opinion on Investigational Drugs | volume = 9 | issue = 10 | pages = 2259–2267(9) |date=October 2000 | doi = 10.1517/13543784.9.10.2259 | url = http://www.ingentaconnect.com/content/apl/eid/2000/00000009/00000010/art00004}}
3. ^{{cite journal |vauthors=Mashkovskii MD, Glushkov RG | title = Drugs for the Treatment of Alzheimer's Disease | journal = Pharmaceutical Chemistry Journal | volume = 35 | issue = 4 | pages = 179–182 |date=April 2001 | doi = 10.1023/A:1010474325601 | url = http://www.springerlink.com/content/w5vq328733t2v601/}}
{{Nootropics}}{{Anti-dementia drugs}}{{Muscarinic acetylcholine receptor modulators}}

3 : Muscarinic agonists|Tetrahydropyridines|Thiadiazoles

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