词条 | Tazomeline |
释义 |
| IUPAC_name = 5-[4-(hexylsulfanyl)-1,2,5-thiadiazol-3-yl]-1-methyl-1,2,3,6-tetrahydropyridine | image = Tazomeline.png | tradename = | pregnancy_category = | legal_status = | routes_of_administration = | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 131987-54-7 | ATC_prefix = None | ATC_suffix = | PubChem = 131460 | ChemSpiderID = 116193 | ChEMBL = 131819 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = QDP6S14W5W | C=14 | H=23 | N=3 | S=2 | molecular_weight = 297.48 g/mol | smiles = n2snc(/C1=C/CCN(C)C1)c2SCCCCCC }}Tazomeline (LY-287,041) is a drug which acts as a non-selective muscarinic acetylcholine receptor agonist.[1][2] It was in clinical trials for the treatment of cognitive dysfunction such as that seen in Alzheimer's disease and schizophrenia, but development was apparently scrapped for unknown reasons.[1][2][3] See also
References1. ^1 {{cite journal |vauthors=Langmead CJ, Watson J, Reavill C | title = Muscarinic acetylcholine receptors as CNS drug targets | journal = Pharmacology & Therapeutics | volume = 117 | issue = 2 | pages = 232–43 |date=February 2008 | pmid = 18082893 | doi = 10.1016/j.pharmthera.2007.09.009 | url = http://linkinghub.elsevier.com/retrieve/pii/S0163-7258(07)00207-0}} {{Nootropics}}{{Anti-dementia drugs}}{{Muscarinic acetylcholine receptor modulators}}2. ^1 {{cite journal | author = Amos D Korczyn | title = Muscarinic M1 Agonists in the Treatment of Alzheimer's Disease | journal = Expert Opinion on Investigational Drugs | volume = 9 | issue = 10 | pages = 2259–2267(9) |date=October 2000 | doi = 10.1517/13543784.9.10.2259 | url = http://www.ingentaconnect.com/content/apl/eid/2000/00000009/00000010/art00004}} 3. ^{{cite journal |vauthors=Mashkovskii MD, Glushkov RG | title = Drugs for the Treatment of Alzheimer's Disease | journal = Pharmaceutical Chemistry Journal | volume = 35 | issue = 4 | pages = 179–182 |date=April 2001 | doi = 10.1023/A:1010474325601 | url = http://www.springerlink.com/content/w5vq328733t2v601/}} 3 : Muscarinic agonists|Tetrahydropyridines|Thiadiazoles |
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