| 释义 |
- References
- Further reading
{{Underlinked|date=June 2016}}{{Infobox_gene}}Tubulin-specific chaperone A is a protein that in humans is encoded by the TBCA gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A.[3]
}}References1. ^{{cite journal | vauthors = Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z | title = Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 14 | pages = 8175–80 |date=Aug 1998 | pmid = 9653160 | pmc = 20949 | doi =10.1073/pnas.95.14.8175 }}
2. ^{{cite journal | vauthors = Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ | title = Pathway leading to correctly folded beta-tubulin | journal = Cell | volume = 86 | issue = 2 | pages = 287–96 |date=Sep 1996 | pmid = 8706133 | pmc = | doi =10.1016/S0092-8674(00)80100-2 }}
3. ^1 {{cite web | title = Entrez Gene: TBCA tubulin folding cofactor A| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6902| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Lewis SA, Tian G, Vainberg IE, Cowan NJ |title=Chaperonin-mediated folding of actin and tubulin |journal=J. Cell Biol. |volume=132 |issue= 1–2 |pages= 1–4 |year= 1996 |pmid= 8567715 |doi=10.1083/jcb.132.1.1 | pmc=2120700 }}
- {{cite journal |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 }}
- {{cite journal |vauthors=Guasch A, Aloria K, Pérez R, etal |title=Three-dimensional structure of human tubulin chaperone cofactor A |journal=J. Mol. Biol. |volume=318 |issue= 4 |pages= 1139–49 |year= 2002 |pmid= 12054808 |doi= 10.1016/S0022-2836(02)00185-7 |hdl=10261/109021 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Nolasco S, Bellido J, Gonçalves J, etal |title=Tubulin cofactor A gene silencing in mammalian cells induces changes in microtubule cytoskeleton, cell cycle arrest and cell death |journal=FEBS Lett. |volume=579 |issue= 17 |pages= 3515–24 |year= 2005 |pmid= 15963512 |doi= 10.1016/j.febslet.2005.05.022 }}
- {{cite journal |vauthors=Bruneel A, Labas V, Mailloux A, etal |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis |journal=Proteomics |volume=5 |issue= 15 |pages= 3876–84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239 }}
{{refend}}{{PDB Gallery|geneid=6902}}{{gene-5-stub}} |