| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}Transcription elongation factor A protein 2 is a protein that in humans is encoded by the TCEA2 gene.[1][2][3] Function The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.[3] Interactions TCEA2 has been shown to interact with MAGEA11.[4] References 1. ^{{cite journal | vauthors = Weaver ZA, Kane CM | title = Genomic characterization of a testis-specific TFIIS (TCEA2) gene | journal = Genomics | volume = 46 | issue = 3 | pages = 516–9 | date = Dec 1997 | pmid = 9441762 | pmc = | doi = 10.1006/geno.1997.5073 }}
2. ^{{cite journal | vauthors = Umehara T, Kida S, Yamamoto T, Horikoshi M | title = Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II | journal = Gene | volume = 167 | issue = 1-2 | pages = 297–302 | date = Dec 1995 | pmid = 8566795 | pmc = | doi = 10.1016/0378-1119(95)00634-6 }}
3. ^1 {{cite web | title = Entrez Gene: TCEA2 transcription elongation factor A (SII), 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6919| accessdate = }}
4. ^{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG | title = HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors | journal = Genes & Development | volume = 6 | issue = 4 | pages = 655–66 | date = Apr 1992 | pmid = 1559613 | doi = 10.1101/gad.6.4.655 }}
- {{cite journal | vauthors = Li XY, Green MR | title = The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor | journal = Genes & Development | volume = 12 | issue = 19 | pages = 2992–6 | date = Oct 1998 | pmid = 9765201 | pmc = 317190 | doi = 10.1101/gad.12.19.2992 }}
- {{cite journal | vauthors = Trembley JH, Hu D, Hsu LC, Yeung CY, Slaughter C, Lahti JM, Kidd VJ | title = PITSLRE p110 protein kinases associate with transcription complexes and affect their activity | journal = The Journal of Biological Chemistry | volume = 277 | issue = 4 | pages = 2589–96 | date = Jan 2002 | pmid = 11709559 | doi = 10.1074/jbc.M109755200 }}
- {{cite journal | vauthors = Sijbrandi R, Fiedler U, Timmers HT | title = RNA polymerase II complexes in the very early phase of transcription are not susceptible to TFIIS-induced exonucleolytic cleavage | journal = Nucleic Acids Research | volume = 30 | issue = 11 | pages = 2290–8 | date = Jun 2002 | pmid = 12034815 | pmc = 117193 | doi = 10.1093/nar/30.11.2290 }}
- {{cite journal | vauthors = Saso K, Ito T, Natori S, Sekimizu K | title = Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II | journal = Journal of Biochemistry | volume = 133 | issue = 4 | pages = 493–500 | date = Apr 2003 | pmid = 12761297 | doi = 10.1093/jb/mvg065 }}
- {{cite journal | vauthors = Tamura K, Miyata K, Sugahara K, Onishi S, Shuin T, Aso T | title = Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain | journal = Biochemical and Biophysical Research Communications | volume = 309 | issue = 1 | pages = 189–95 | date = Sep 2003 | pmid = 12943681 | doi = 10.1016/S0006-291X(03)01556-0 }}
- {{cite journal | vauthors = Nakata A, Ito T, Nagata M, Hori S, Sekimizu K | title = GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1 | journal = Genes to Cells | volume = 9 | issue = 11 | pages = 1125–35 | date = Nov 2004 | pmid = 15507123 | doi = 10.1111/j.1365-2443.2004.00795.x }}
- {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
- {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
- {{cite journal | vauthors = Palangat M, Renner DB, Price DH, Landick R | title = A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 42 | pages = 15036–41 | date = Oct 2005 | pmid = 16214896 | pmc = 1257689 | doi = 10.1073/pnas.0409405102 }}
- {{cite journal | vauthors = Kuraoka I, Suzuki K, Ito S, Hayashida M, Kwei JS, Ikegami T, Handa H, Nakabeppu Y, Tanaka K | title = RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS | journal = DNA Repair | volume = 6 | issue = 6 | pages = 841–51 | date = Jun 2007 | pmid = 17374514 | doi = 10.1016/j.dnarep.2007.01.014 }}
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