| 词条 | T-cell receptor excision circles |
| 释义 |
T-cell receptor excision circles (TRECs) are small circles of DNA created in T-cells during their passage through the thymus as they rearrange their TCR genes.[1] Their presence indicates maturation of T cells; TRECs are reduced in SCID (Severe combined immunodeficiency disease). Signal joint T-cell receptor excision circles (sjTRECs) might be used as a way to test the age of the individual from a blood sample.[2] The detection of sjTRECs can be further used as a diagnostic tool to monitor the thymic output (e.g., following hematopoietic stem cell transplantation or in cases of AIDS).[3] See also
References1. ^http://allergycases.org/2010/05/t-cell-receptor-excision-circles-trecs.html{{full|date=September 2018}} {{Genetics-stub}}2. ^ [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026262/]{{full|date=September 2018}} 3. ^{{cite journal |vauthors=Al-Harthi L, Marchetti G, Steffens CM, Poulin J, Sékaly R, Landay A |title=Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA) |journal=Journal of Immunological Methods |volume=237 |issue=1-2 |pages=187–97 |year=2000 |pmid=10725462 |doi=10.1016/S0022-1759(00)00136-8 }} 1 : T cells |
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