| 词条 | TCF/LEF family |
| 释义 |
The TCF/LEF family is a group of transcription factors which bind to DNA through a high mobility group domain. They are involved in the Wnt signaling pathway, where they recruit the coactivator beta-catenin to enhancer elements of genes they target. They can also recruit members of the Groucho family of corepressors.[1] Human members
References1. ^{{cite journal |vauthors=Brantjes H, Barker N, van Es J, Clevers H |title=TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling |journal=Biol. Chem. |volume=383 |issue=2 |pages=255–61 |date=February 2002 |pmid=11934263 |doi=10.1515/BC.2002.027}} {{DEFAULTSORT:TCF LEF family}}{{genetics-stub}} 2 : Developmental genes and proteins|Transcription factors |
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