| 释义 |
- Function
- References
- Further reading
- External links
{{Infobox_gene}}TCIM is a protein that in humans is encoded by the TCIM gene.[1][2] Function This gene encodes a small, monomeric, predominantly unstructured protein (106 amino acids, 12.3 kDa, isoelectric point 9.39).[3] It is a positive regulator of the Wnt / beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes.[2] References 1. ^{{cite journal | vauthors = Chua EL, Young L, Wu WM, Turtle JR, Dong Q | title = Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer | journal = Genomics | volume = 69 | issue = 3 | pages = 342–7 | date = November 2000 | pmid = 11056052 | pmc = | doi = 10.1006/geno.2000.6348 }}
2. ^1 {{cite web | title = Entrez Gene: C8orf4 chromosome 8 open reading frame 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56892| accessdate = }}
3. ^{{cite journal | vauthors = Kozlowski LP | title = IPC - Isoelectric Point Calculator | journal = Biology Direct | volume = 11 | issue = 1 | pages = 55 | date = October 2016 | pmid = 27769290 | doi = 10.1186/s13062-016-0159-9 | url = http://isoelectric.ovh.org | pmc=5075173}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
- {{cite journal | vauthors = Sunde M, McGrath KC, Young L, Matthews JM, Chua EL, Mackay JP, Death AK | title = TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer | journal = Cancer Research | volume = 64 | issue = 8 | pages = 2766–73 | date = April 2004 | pmid = 15087392 | doi = 10.1158/0008-5472.CAN-03-2093 }}
- {{cite journal | vauthors = Friedman JB, Brunschwig EB, Platzer P, Wilson K, Markowitz SD | title = C8orf4 is a transforming growth factor B induced transcript downregulated in metastatic colon cancer | journal = International Journal of Cancer | volume = 111 | issue = 1 | pages = 72–5 | date = August 2004 | pmid = 15185345 | doi = 10.1002/ijc.20235 }}
- {{cite journal | vauthors = Jung Y, Bang S, Choi K, Kim E, Kim Y, Kim J, Park J, Koo H, Moon RT, Song K, Lee I | title = TC1 (C8orf4) enhances the Wnt/beta-catenin pathway by relieving antagonistic activity of Chibby | journal = Cancer Research | volume = 66 | issue = 2 | pages = 723–8 | date = January 2006 | pmid = 16424001 | doi = 10.1158/0008-5472.CAN-05-3124 }}
- {{cite journal | vauthors = Kim B, Koo H, Yang S, Bang S, Jung Y, Kim Y, Kim J, Park J, Moon RT, Song K, Lee I | title = TC1(C8orf4) correlates with Wnt/beta-catenin target genes and aggressive biological behavior in gastric cancer | journal = Clinical Cancer Research | volume = 12 | issue = 11 Pt 1 | pages = 3541–8 | date = June 2006 | pmid = 16740781 | doi = 10.1158/1078-0432.CCR-05-2440 }}
- {{cite journal | vauthors = Yang ZQ, Streicher KL, Ray ME, Abrams J, Ethier SP | title = Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer | journal = Cancer Research | volume = 66 | issue = 24 | pages = 11632–43 | date = December 2006 | pmid = 17178857 | doi = 10.1158/0008-5472.CAN-06-2946 }}
- {{cite journal | vauthors = Yang ZQ, Moffa AB, Haddad R, Streicher KL, Ethier SP | title = Transforming properties of TC-1 in human breast cancer: interaction with FGFR2 and beta-catenin signaling pathways | journal = International Journal of Cancer | volume = 121 | issue = 6 | pages = 1265–73 | date = September 2007 | pmid = 17520678 | doi = 10.1002/ijc.22831 }}
- {{cite journal | vauthors = Park J, Jung Y, Kim J, Kim KY, Ahn SG, Song K, Lee I | title = TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response | journal = Biochemical and Biophysical Research Communications | volume = 360 | issue = 2 | pages = 447–52 | date = August 2007 | pmid = 17603013 | doi = 10.1016/j.bbrc.2007.06.077 }}
{{refend}}External links- {{UCSC gene info|C8orf4}}
{{gene-8-stub}} |