| 词条 | Telomestatin |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 400875358 | ImageFile = Telomestatin.png | ImageSize = 200px | ImageAlt = | IUPACName = | OtherNames = |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo = 265114-54-3 | PubChem = 11954679 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 443683 | SMILES = CC1=C(C2=NC(C3=NC(C4=NC(C5=NC(C6=NC(C7=NC(C8=N[C@@]9([H])CS8)=CO7)=CO6)=CO5)=CO4)=CO3)=C(C)O2)N=C9O1 }} |Section2={{Chembox Properties | C=26 | H=14 | N=8 | O=7 | S=1 | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }} Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of in vitro cancer cells.[1] It was first isolated from the bacteria Streptomyces anulatus.[1] Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence. References1. ^1 {{cite journal | doi = 10.1021/ja005780q |author1=Shin-ya, Kazuo |author2=Wierzba, Konstanty |author3=Matsuo, Ken-ichi |author4=Ohtani, Toshio |author5=Yamada, Yuji |author6=Furihata, Kazuo |author7=Hayakawa, Yoichi |author8=Seto, Haruo | title = Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus | journal = Journal of the American Chemical Society | year = 2001 | volume = 123 | issue = 6 | pages = 1262–1263 | pmid = 11456694}} 4 : Macrocycles|Oxazoles|Thiazolines|Telomeres |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。