1. Function

2. References

3. Further reading

Function

Tenascin-R (TNR) is an extracellular matrix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion), TNX (TNXB), and TNR.^[4] The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM]^[3]

References

Further reading

• {{cite journal | vauthors = Erickson HP | title = Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions | journal = Current Opinion in Cell Biology | volume = 5 | issue = 5 | pages = 869–76 | date = October 1993 | pmid = 7694605 | doi = 10.1016/0955-0674(93)90037-Q }}
• {{cite journal | vauthors = Xiao ZC, Taylor J, Montag D, Rougon G, Schachner M | title = Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11 | journal = The European Journal of Neuroscience | volume = 8 | issue = 4 | pages = 766–82 | date = April 1996 | pmid = 9081628 | doi = 10.1111/j.1460-9568.1996.tb01262.x }}
• {{cite journal | vauthors = Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y | title = The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 19 | pages = 10116–21 | date = September 1997 | pmid = 9294172 | pmc = 23322 | doi = 10.1073/pnas.94.19.10116 }}
• {{cite journal | vauthors = Xiao ZC, Hillenbrand R, Schachner M, Thermes S, Rougon G, Gomez S | title = Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin-R | journal = Journal of Neuroscience Research | volume = 49 | issue = 6 | pages = 698–709 | date = September 1997 | pmid = 9335257 | doi = 10.1002/(SICI)1097-4547(19970915)49:6<698::AID-JNR4>3.0.CO;2-2 }}
• {{cite journal | vauthors = Arrigo G, Gherzi R, Bonaglia MC, Leprini A, Zuffardi O, Zardi L | title = Assignment of the tenascin-R gene (Tnr) to mouse chromosome 4 band E2 by fluorescence in situ hybridization; refinement of the human TNR location to chromosome 1q24 | journal = Cytogenetics and Cell Genetics | volume = 78 | issue = 2 | pages = 145–6 | year = 1997 | pmid = 9371410 | doi = 10.1159/000134650 }}
• {{cite journal | vauthors = Volkmer H, Zacharias U, Nörenberg U, Rathjen FG | title = Dissection of complex molecular interactions of neurofascin with axonin-1, F11, and tenascin-R, which promote attachment and neurite formation of tectal cells | journal = The Journal of Cell Biology | volume = 142 | issue = 4 | pages = 1083–93 | date = August 1998 | pmid = 9722619 | pmc = 2132869 | doi = 10.1083/jcb.142.4.1083 }}
• {{cite journal | vauthors = Zamze S, Harvey DJ, Pesheva P, Mattu TS, Schachner M, Dwek RA, Wing DR | title = Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans | journal = Glycobiology | volume = 9 | issue = 8 | pages = 823–31 | date = August 1999 | pmid = 10406848 | doi = 10.1093/glycob/9.8.823 }}
• {{cite journal | vauthors = Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A | title = The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding | journal = The Journal of Biological Chemistry | volume = 276 | issue = 2 | pages = 1253–61 | date = January 2001 | pmid = 11038354 | doi = 10.1074/jbc.M006783200 }}
• {{cite journal | vauthors = Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG | title = Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 26 | pages = 15089–94 | date = December 2001 | pmid = 11752456 | pmc = 64988 | doi = 10.1073/pnas.241522398 }}
• {{cite journal | vauthors = Woodworth A, Pesheva P, Fiete D, Baenziger JU | title = Neuronal-specific synthesis and glycosylation of tenascin-R | journal = The Journal of Biological Chemistry | volume = 279 | issue = 11 | pages = 10413–21 | date = March 2004 | pmid = 14681222 | doi = 10.1074/jbc.M312466200 }}
• {{cite journal | vauthors = Bukalo O, Schachner M, Dityatev A | title = Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R | journal = The Journal of Neuroscience | volume = 27 | issue = 22 | pages = 6019–28 | date = May 2007 | pmid = 17537973 | doi = 10.1523/JNEUROSCI.1022-07.2007 }}

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