| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Tensin-like C1 domain-containing phosphatase is an enzyme that in humans is encoded by the TENC1 gene.[1]{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[1]
}}InteractionsTENC1 has been shown to interact with AXL receptor tyrosine kinase.[2] References1. ^1 {{cite web | title = Entrez Gene: TENC1 tensin like C1 domain containing phosphatase (tensin 2)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23371| accessdate = }}
2. ^{{cite journal |doi=10.1016/S0006-291X(02)02718-3 |last=Hafizi |first=Sassan |authorlink= |author2=Alindri Filiz |author3=Karlsson Roger |author4=Dahlbäck Björn |date=Dec 2002 |title=Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue=5 |pages=793–800 |publisher= |location = United States| issn = 0006-291X| pmid = 12470648 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Kikuno R, Nagase T, Ishikawa K, etal |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197–205 |year= 1999 |pmid= 10470851 |doi=10.1093/dnares/6.3.197 }}
- {{cite journal |vauthors=Chen H, Duncan IC, Bozorgchami H, Lo SH |title=Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 733–8 |year= 2002 |pmid= 11792844 |doi= 10.1073/pnas.022518699 | pmc=117374 |bibcode=2002PNAS...99..733C }}
- {{cite journal |vauthors=Hafizi S, Alindri F, Karlsson R, Dahlbäck B |title=Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 793–800 |year= 2003 |pmid= 12470648 |doi=10.1016/S0006-291X(02)02718-3 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Calderwood DA, Fujioka Y, de Pereda JM, etal |title=Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2272–7 |year= 2003 |pmid= 12606711 |doi= 10.1073/pnas.262791999 | pmc=151330 |bibcode=2003PNAS..100.2272C }}
- {{cite journal |vauthors=Hu Y, Fang X, Dunham SM, etal |title=90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29325–35 |year= 2004 |pmid= 15117958 |doi= 10.1074/jbc.M311144200 }}
- {{cite journal |vauthors=Hafizi S, Ibraimi F, Dahlbäck B |title=C1-TEN is a negative regulator of the Akt/PKB signal transduction pathway and inhibits cell survival, proliferation, and migration. |journal=FASEB J. |volume=19 |issue= 8 |pages= 971–3 |year= 2006 |pmid= 15817639 |doi= 10.1096/fj.04-2532fje }}
- {{cite journal |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
- {{cite journal |vauthors=Yam JW, Ko FC, Chan CY, etal |title=Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma. |journal=Hepatology |volume=44 |issue= 4 |pages= 881–90 |year= 2006 |pmid= 17006924 |doi= 10.1002/hep.21339 }}
{{refend}}{{PDB Gallery|geneid=23371}}{{Protein tyrosine phosphatases}}{{gene-12-stub}} |