| 词条 | Tezacitabine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 394859833 | ImageFile=Tezacitabine.png | ImageSize=200px | IUPACName=4-Amino-1-[(2R,3E,4S,5R)-3-(fluoromethylidene)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one | OtherNames= |Section1={{Chembox Identifiers | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 7607Y95N9S | CASNo_Ref = {{cascite|correct|??}} | CASNo=130306-02-4 | PubChem=6435808 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4940503 | SMILES=OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)/C([C@@H]1O)=C/F | InChI = 1/C10H12FN3O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-3,6,8-9,15-16H,4H2,(H2,12,13,17)/b5-3+/t6-,8+,9-/m1/s1 | InChIKey = GFFXZLZWLOBBLO-ASKVSEFXBD | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C10H12FN3O4/c11-3-5-8(16)6(4-15)18-9(5)14-2-1-7(12)13-10(14)17/h1-3,6,8-9,15-16H,4H2,(H2,12,13,17)/b5-3+/t6-,8+,9-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = GFFXZLZWLOBBLO-ASKVSEFXSA-N |Section2={{Chembox Properties | C=10 | H=12 | F=1 | N=3 | O=4 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Tezacitabine is a ribonucleotide reductase inhibitor. It is a synthetic purine nucleoside analogue with potential antineoplastic activity. It is used in synthetic DNA.[1] References1. ^{{cite journal |vauthors=Tsimberidou AM, Alvarado Y, Giles FJ |title=Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies |journal=Expert Rev Anticancer Ther |volume=2 |issue=4 |pages=437–48 |date=August 2002 |pmid=12647987 |doi=10.1586/14737140.2.4.437 |url=http://www.future-drugs.com/doi/abs/10.1586/14737140.2.4.437?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dncbi.nlm.nih.gov}} {{organic-compound-stub}} 3 : Nucleosides|Organofluorides|Pyrimidones |
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