| 词条 | Tg-rasH2 mouse |
| 释义 |
A Tg-rasH2 mouse is an innovative transgenic mouse, developed in Central Institute for Experimental Animals (CIEA), carrying the three copies of human prototype c-Ha-ras oncogenes with endogenous promoter and enhancer in tandem.[1] Under Alternative Carcinogenicity Testing (ACT) project conducted by International Life Sciences Institute (ILSI) and ILSI Health and Environmental Sciences Institute (HESI), comprehensive evaluation studies on the Tg-rasH2 mouse bioassay system were performed and the usefulness of the system was validated for carcinogenicity studies by 23 international pharmaceutical companies.[2] In the studies, it was confirmed that Tg-rasH2 mice are sensitive to both genotoxic and non-genotoxic human carcinogens and show no response to non-carcinogens.[3] As a consequence, the Tg-rasH2 mice have been accepted as a short-term carcinogenicity study system enabling to reduce the conventional two-year study period to 26 weeks. {{see also|Ras subfamily}}History
References1. ^Central Institute for Experimental Animals{{Dead link|date=June 2018 |bot=InternetArchiveBot |fix-attempted=no }} 2. ^Background Data{{Dead link|date=November 2018 |bot=InternetArchiveBot |fix-attempted=yes }} 3. ^Tumorigenesis Patterns{{Dead link|date=November 2018 |bot=InternetArchiveBot |fix-attempted=yes }} External links
1 : Immunology mice |
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