请输入您要查询的百科知识：

　

词条 TH1L
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Negative elongation factor C/D is a protein that in humans is encoded by the TH1L gene.[1][2][3]

Function

The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini.[3]

Interactions

TH1L has been shown to interact with:

  • ARAF,[4][5]
  • Cofactor of BRCA1,[7][8] and
  • RDBP.[6][7]

References

1. ^{{cite journal | vauthors = Bonthron DT, Hayward BE, Moran V, Strain L | title = Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13 | journal = Human Genetics | volume = 107 | issue = 2 | pages = 165–75 | date = Aug 2000 | pmid = 11030415 | pmc = | doi = 10.1007/s004390000344 }}
2. ^{{cite journal | vauthors = Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z | title = Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells | journal = Genome Research | volume = 10 | issue = 10 | pages = 1546–60 | date = Oct 2000 | pmid = 11042152 | pmc = 310934 | doi = 10.1101/gr.140200 }}
3. ^1 {{cite web | title = Entrez Gene: TH1L TH1-like (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51497| accessdate = }}
4. ^{{cite journal | vauthors = Yuryev A, Wennogle LP | title = Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis | journal = Genomics | volume = 81 | issue = 2 | pages = 112–25 | date = Feb 2003 | pmid = 12620389 | doi = 10.1016/s0888-7543(02)00008-3}}
5. ^{{cite journal | vauthors = Yin XL, Chen S, Gu JX | title = Identification of TH1 as an interaction partner of A-Raf kinase | journal = Molecular and Cellular Biochemistry | volume = 231 | issue = 1-2 | pages = 69–74 | date = Feb 2002 | pmid = 11952167 | doi = 10.1023/A:1014437024129}}
6. ^1 {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = | pages = 89 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 | year=2007}}
7. ^1 {{cite journal | vauthors = Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H | title = Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 1863–73 | date = Mar 2003 | pmid = 12612062 | pmc = 149481 | doi = 10.1128/mcb.23.6.1863-1873.2003}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Stevens M, De Clercq E, Balzarini J | title = The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention | journal = Medicinal Research Reviews | volume = 26 | issue = 5 | pages = 595–625 | date = Sep 2006 | pmid = 16838299 | doi = 10.1002/med.20081 }}
  • {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
  • {{cite journal | vauthors = Yamaguchi Y, Takagi T, Wada T, Yano K, Furuya A, Sugimoto S, Hasegawa J, Handa H | title = NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation | journal = Cell | volume = 97 | issue = 1 | pages = 41–51 | date = Apr 1999 | pmid = 10199401 | doi = 10.1016/S0092-8674(00)80713-8 }}
  • {{cite journal | vauthors = Ping YH, Rana TM | title = DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 16 | pages = 12951–8 | date = Apr 2001 | pmid = 11112772 | doi = 10.1074/jbc.M006130200 }}
  • {{cite journal | vauthors = Yin XL, Chen S, Gu JX | title = Identification of TH1 as an interaction partner of A-Raf kinase | journal = Molecular and Cellular Biochemistry | volume = 231 | issue = 1-2 | pages = 69–74 | date = Feb 2002 | pmid = 11952167 | doi = 10.1023/A:1014437024129 }}
  • {{cite journal | vauthors = Narita T, Yamaguchi Y, Yano K, Sugimoto S, Chanarat S, Wada T, Kim DK, Hasegawa J, Omori M, Inukai N, Endoh M, Yamada T, Handa H | title = Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 1863–73 | date = Mar 2003 | pmid = 12612062 | pmc = 149481 | doi = 10.1128/MCB.23.6.1863-1873.2003 }}
  • {{cite journal | vauthors = Yuryev A, Wennogle LP | title = Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis | journal = Genomics | volume = 81 | issue = 2 | pages = 112–25 | date = Feb 2003 | pmid = 12620389 | doi = 10.1016/S0888-7543(02)00008-3 }}
  • {{cite journal | vauthors = Liu W, Shen X, Yang Y, Yin X, Xie J, Yan J, Jiang J, Liu W, Wang H, Sun M, Zheng Y, Gu J | title = Trihydrophobin 1 is a new negative regulator of A-Raf kinase | journal = The Journal of Biological Chemistry | volume = 279 | issue = 11 | pages = 10167–75 | date = Mar 2004 | pmid = 14684750 | doi = 10.1074/jbc.M307994200 }}
  • {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
  • {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
  • {{cite journal | vauthors = Yang Y, Liu W, Zou W, Wang H, Zong H, Jiang J, Wang Y, Gu J | title = Ubiquitin-dependent proteolysis of trihydrophobin 1 (TH1) by the human papilloma virus E6-associated protein (E6-AP) | journal = Journal of Cellular Biochemistry | volume = 101 | issue = 1 | pages = 167–80 | date = May 2007 | pmid = 17131388 | doi = 10.1002/jcb.21164 }}
{{refend}}{{gene-20-stub}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/11/10 12:03:16