“Thiamine diphosphokinase”的意思、由来-开放百科全书

词条

Thiamine diphosphokinase

释义

Structural studies
References

{{enzyme
| Name = thiamin diphosphokinase
| EC_number = 2.7.6.2
| CAS_number = 9026-24-8
| IUBMB_EC_number = 2/7/6/2
| GO_code = 0004788
| image =
| width =
| caption =
}}

In enzymology, a thiamine diphosphokinase ({{EC number|2.7.6.2}}) is an enzyme that catalyzes the chemical reaction

ATP + thiamine AMP + thiamine diphosphate

Thus, the two substrates of this enzyme are ATP and thiamine, whereas its two products are AMP and thiamine diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring two phosphorus-containing groups (diphosphotransferases). The systematic name of this enzyme class is ATP:thiamine diphosphotransferase. Other names in common use include thiamin kinase, thiamine pyrophosphokinase, ATP:thiamin pyrophosphotransferase, thiamin pyrophosphokinase, thiamin pyrophosphotransferase, thiaminokinase, thiamin:ATP pyrophosphotransferase, and TPTase. This enzyme participates in thiamine metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1IG0}}, {{PDB link|1IG3}}, {{PDB link|2F17}}, {{PDB link|2G9Z}}, {{PDB link|2HH9}}, and {{PDB link|2OMK}}.

References

{{cite journal |author1 = Leuthardt F |author2 =Nielsen H | date = 1952 | title = Phosphorylation biologique de la thiamine | journal = Helv. Chim. Acta | volume = 35 | issue = 4 | pages = 1196–1209 | doi = 10.1002/hlca.19520350415 }}
{{cite journal | vauthors = Shimazono N, Mano Y, Tanaka R, Kajiro Y | location = Tokyo | title = Mechanism of transpyrophosphorylation with thiamine pyrophosphokinase | journal = J. | volume = Biochem. | pages = 959–961 }}
{{cite journal | author = Steyn-Parve EP | date = 1952 | title = Partial purification and properties of thiaminokinase from yeast | journal = Biochim. Biophys. Acta | volume = 8 | issue = 3 | pages = 310–324 | doi = 10.1016/0006-3002(52)90046-2 | pmid=14934742}}

{{Metabolism of vitamins, coenzymes, and cofactors}}{{Kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{2.7-enzyme-stub}}

2 : EC 2.7.6|Enzymes of known structure

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