“Thiocyanate hydrolase”的意思、由来-开放百科全书

词条

Thiocyanate hydrolase

释义

Structural studies
References

{{enzyme
| Name = thiocyanate hydrolase
| EC_number = 3.5.5.8
| CAS_number =
| IUBMB_EC_number = 3/5/5/8
| GO_code = 0018760
| image =
| width =
| caption =
}}

In enzymology, a thiocyanate hydrolase ({{EC number|3.5.5.8}}) is an enzyme that catalyzes the chemical reaction

thiocyanate + 2 H₂O carbonyl sulfide + NH₃ + HO-

Thus, the two substrates of this enzyme are thiocyanate and H₂O, whereas its 3 products are carbonyl sulfide, NH₃, and HO-.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is thiocyanate aminohydrolase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2DD4}}, {{PDB link|2DD5}}, {{PDB link|2DXB}}, and {{PDB link|2DXC}}.

References

{{cite journal | vauthors = Katayama Y, Matsushita Y, Kaneko M, Kondo M, Mizuno T, Nyunoya H | date = 1998 | title = Cloning of genes coding for the three subunits of thiocyanate hydrolase of Thiobacillus thioparus THI 115 and their evolutionary relationships to nitrile hydratase | journal = J. Bacteriol. | volume = 180 | pages = 2583–9 | pmid = 9573140 | issue = 10 | pmc = 107207 }}
{{cite journal | vauthors = Katayama Y, Narahara Y, Inoue Y, Amano F, Kanagawa T, Kuraishi H | date = 1992 | title = A thiocyanate hydrolase of Thiobacillus thioparus. A novel enzyme catalyzing the formation of carbonyl sulfide from thiocyanate | journal = J. Biol. Chem. | volume = 267 | pages = 9170–5 | pmid = 1577754 | issue = 13 }}

{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.5-enzyme-stub}}

2 : EC 3.5.5|Enzymes of known structure

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