“Thymidine kinase from herpesvirus”的意思、由来-开放百科全书

词条

Thymidine kinase from herpesvirus

释义

References

{{Pfam_box
| Symbol = Herpes_TK
| Name = Thymidine kinase from herpesvirus
| image = PDB_1kim_EBI.jpg
| width =
| caption = Structure of thymidine kinase from herpesvirus.^[1]
| Pfam= PF00693
| InterPro= IPR001889
| SMART=
| PROSITE =
| SCOP = 1kin
| TCDB =
| OPM family=
| OPM protein=
| PDB={{PDB3|1e2p}}B:56-330 {{PDB3|1e2j}}B:56-330 {{PDB3|1vtk}} :56-330{{PDB3|1of1}}B:56-330 {{PDB3|1e2l}}A:56-330 {{PDB3|1e2k}}A:56-330{{PDB3|1p7c}}A:56-330 {{PDB3|1e2m}}B:56-330 {{PDB3|1ki6}}A:56-330{{PDB3|1e2h}}B:56-330 {{PDB3|3vtk}} :56-330 {{PDB3|1e2n}}A:56-330{{PDB3|1e2i}}B:56-330 {{PDB3|2vtk}} :56-330 {{PDB3|1osn}}C:19-299{{PDB3|1p72}}A:32-309 {{PDB3|1p75}}B:32-309 {{PDB3|1p73}}D:32-309{{PDB3|1p6x}}A:32-309
}}Thymidine kinase from herpesvirus is a sub-family of thymidine kinases.^[2]

Its presence in herpesvirus-infected cells is used to activate a range of antivirals against herpes infection, and thus specifically target the therapy towards infected cells only.

Such antivirals include:

Purine analogues of guanine: Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir
Vidarabine
Pyrimidine analogues of uridine: Idoxuridine, Trifluridine
Brivudine

Mutations in the gene coding thymidine kinase in herpes viruses can endow the virus with resistance to aciclovir. In these situations, alternative medications that are of use include other guanine analogues such as famciclovir, valaciclovir and penciclovir.

References

1. ^{{cite journal |vauthors=Champness JN, Bennett MS, Wien F, etal |title=Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands |journal=Proteins |volume=32 |issue=3 |pages=350–61 |date=August 1998 |pmid=9715911 |doi= 10.1002/(SICI)1097-0134(19980815)32:3<350::AID-PROT10>3.0.CO;2-8|url=}}
2. ^{{cite journal | vauthors = Brown DG, Visse R, Sandhu G, Davies A, Rizkallah PJ, Melitz C, Summers WC, Sanderson MR | title = Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir | journal = Nat. Struct. Biol. | volume = 2 | issue = 10 | pages = 876–81 |date=October 1995 | pmid = 7552712 | doi = 10.1038/nsb1095-876| url = | issn = }}

2 : Protein families|Viral enzymes

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