“Thyroglobulin domain”的意思、由来-开放百科全书

词条

Thyroglobulin domain

释义

Human proteins containing this domain
References

{{Pfam_box
| Symbol = Thyroglobulin_1
| Name = Thyroglobulin type-1 repeat
| image = Protein CD74 PDB 1icf.png
| width = 200
| caption = Thyroglobulin type-1 domain
| Pfam= PF00086
| InterPro= IPR000716
| SMART=
| PROSITE = PDOC00377
| SCOP = 1icf
| TCDB =
| CDD = cd00191
| OPM family=
| OPM protein=
| PDB={{PDB3|1icf}}I:213-271 {{PDB3|1l3h}}A:213-271 {{PDB3|1rmj}}A:163-234{{PDB3|1zt3}}A:176-251 {{PDB3|1zt5}}A:176-251
}}

Thyroglobulin type-1 repeat is an evolutionary conserved protein domain.

Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.

Human proteins containing this domain

CD74; IGFBP-4; IGFBP1; IGFBP2; IGFBP3; IGFBP4; IGFBP5; IGFBP6;

NID1; NID2; SMOC1; SMOC2; SPOCK1; SPOCK2; SPOCK3; TACSTD1;

TACSTD2; TG;

References

{{cite journal | vauthors = Guncar G, Pungercic G, Klemencic I, Turk V, Turk D | title = Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S | journal = The EMBO Journal | volume = 18 | issue = 4 | pages = 793–803 | date = February 1999 | pmid = 10022822 | pmc = 1171172 | doi = 10.1093/emboj/18.4.793 }}
{{cite journal | vauthors = Molina F, Bouanani M, Pau B, Granier C | title = Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families | journal = European Journal of Biochemistry | volume = 240 | issue = 1 | pages = 125–33 | date = August 1996 | pmid = 8797845 | doi = 10.1111/j.1432-1033.1996.0125h.x }}

2 : Protein domains|Single-pass transmembrane proteins

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