| 词条 | Tiflorex |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 449587989 | IUPAC_name = (RS)-N-ethyl-1- | image = Tiflorex.svg | width = 260px | chirality = Racemic mixture | drug_name = | tradename = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 53993-67-2 | ATC_prefix = none | PubChem = 173669 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = EG3B69DFQ5 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 151574 | C=12 | H=16 | F=3 | N=1 | S=1 | molecular_weight = 263.10 g/mol | synonyms = | smiles = CCNC(C)Cc1cccc(c1)SC(F)(F)F | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C12H16F3NS/c1-3-16-9(2)7-10-5-4-6-11(8-10)17-12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = HNONSDNCRNUTCT-UHFFFAOYSA-N }}Tiflorex, formerly known as flutiorex, is a stimulant amphetamine. Its most pronounced effect is in suppression of appetite; it has little effect on pulse rate, sleep, or mood.[1] It was found to be twice as potent an anorectic as fenfluramine.[2] SL 72.340-d was cited to be 4x the anorectant potency of fenfluramine (ED50=1.4 mg/kg vs 5.6 mg/kg).[3] References1. ^T. Silverstone, Jill Fincham & Jill Plumley. An evaluation of the anorectic activity in man of a sustained release formulation of tiflorex. British Journal of Clinical Pharmacology, 1979, 7, 353–356. {{Stimulants}}{{Monoamine releasing agents}}{{Phenethylamines}}{{nervous-system-drug-stub}}2. ^{{cite journal | author = J.F. Giudicelli, Christine Richer & A. Berdeaux | title = Preliminary assessment of flutiorex, a new anorectic drug, in man. | journal = British Journal of Clinical Pharmacology | year = 1976 | volume = 3 | issue = 1 | pages = 113–121 | pmid = 788737 | pmc = 1428817 | doi=10.1111/j.1365-2125.1976.tb00578.x}} 3. ^https://books.google.com/books?id=z_8kBQAAQBAJ&pg=PA356&lpg=PA356&dq=SL+72.340-d&source=bl&ots=Oe8zjyf7jX&sig=O5StbScjQ3jWdZ7dafliN7H3GkM&hl=en&sa=X&ved=0ahUKEwiw35Ho5eDMAhWNF8AKHW7CC8IQ6AEIHDAA#v=onepage&q=SL%2072.340-d&f=true 4 : Anorectics|Trifluoromethyl compounds|Substituted amphetamines|Thioethers |
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