| 词条 | Tingible body macrophage |
| 释义 |
A tingible body macrophage is a type of macrophage predominantly found in germinal centers, containing many phagocytized, apoptotic cells in various states of degradation, referred to as tingible bodies (tingible meaning stainable).[1] Tingible body macrophages contain condensed chromatin fragments.[2] It is thought that they may play a role in downregulating the germinal center reaction by the release of prostaglandins and hence a reduced B-cell induction of IL-2.[3] Macrophages that contain debris from ingested lymphocytes are characteristic of a reactive follicular center in benign reactive lymphadenitis. Other accompanying signs of a benign follicular hyperplasia are well developed germinal centers with dark and light zones, in addition to numerous mitotic figures. References1. ^Horst Ibelgaufts' COPE: Cytokines & Cells Online Pathfinder Encyclopaedia > tingible body macrophages Retrieved on June 27, 2010 {{Immunology-stub}}2. ^{{Cite journal|author=MacLennan I.C.M |title=Germinal Centers |journal=Annual Review of Immunology |volume=12 |issue= |pages=117–139 |year=1994 |month= |pmid=8011279 |pmc= |doi= 10.1146/annurev.iy.12.040194.001001|url=}} 3. ^{{Cite journal|vauthors=Smith JP, Burton GF, Tew JG, Szakal AK |title=Tingible body macrophages in regulation of germinal center reactions. |journal=Developmental Immunology |volume=6 |issue= 3-4|pages=285–294 |year=1998 |month= |pmid=9814602 |pmc= 2276033|doi= 10.1155/1998/38923|url=}} 1 : Macrophages |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。