| 释义 |
- References
- Further reading
{{Underlinked|date=June 2016}}{{Infobox_gene}}Tuberoinfundibular peptide of 39 residues is a protein that in humans is encoded by the PTH2 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = TIP39 is related to parathyroid hormone (PTH; MIM 168450) and PTH-related protein (PTHRP; MIM 168470) and is a ligand for PTH receptor-2 (PTHR2; MIM 601469) (John et al., 2002).[supplied by OMIM][3]The molecular interaction of TIP39 with the PTH2 receptor has been characterized in full 3D molecular detail, identifying among other residues, Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding [4]
}}References1. ^{{cite journal | vauthors = John MR, Arai M, Rubin DA, Jonsson KB, Juppner H | title = Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues | journal = Endocrinology | volume = 143 | issue = 3 | pages = 1047–57 |date=Feb 2002 | pmid = 11861531 | pmc = | doi =10.1210/en.143.3.1047 }}
2. ^{{cite web | title = Entrez Gene: TIP39 tuberoinfundibular 39 residue protein precursor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113091| accessdate = }}
3. ^{{cite web | title = Entrez Gene: TIP39 tuberoinfundibular 39 residue protein precursor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113091| accessdate = }}
4. ^{{cite journal |vauthors=Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D |title=High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. |journal=Biochemical Pharmacology |volume= 127|issue= |pages= 71–81|year= 2017 |pmid= 28012961|pmc=5303546 |doi= 10.1016/j.bcp.2016.12.013 }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Usdin TB, Hoare SR, Wang T, etal |title=TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. |journal=Nat. Neurosci. |volume=2 |issue= 11 |pages= 941–3 |year= 1999 |pmid= 10526330 |doi= 10.1038/14724 }}
- {{cite journal | vauthors=Hoare SR, Clark JA, Usdin TB |title=Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27274–83 |year= 2000 |pmid= 10854439 |doi= 10.1074/jbc.M003910200 }}
- {{cite journal |vauthors=Dobolyi A, Ueda H, Uchida H, etal |title=Anatomical and physiological evidence for involvement of tuberoinfundibular peptide of 39 residues in nociception. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 3 |pages= 1651–6 |year= 2002 |pmid= 11818570 |doi= 10.1073/pnas.042416199 | pmc=122245 }}
- {{cite journal |vauthors=Hansen IA, Jakob O, Wortmann S, etal |title=Characterization of the human and mouse genes encoding the tuberoinfundibular peptide of 39 residues, a ligand of the parathyroid hormone receptor family. |journal=J. Endocrinol. |volume=174 |issue= 1 |pages= 95–102 |year= 2002 |pmid= 12098667 |doi=10.1677/joe.0.1740095 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Della Penna K, Kinose F, Sun H, etal |title=Tuberoinfundibular peptide of 39 residues (TIP39): molecular structure and activity for parathyroid hormone 2 receptor. |journal=Neuropharmacology |volume=44 |issue= 1 |pages= 141–53 |year= 2003 |pmid= 12559132 |doi=10.1016/S0028-3908(02)00335-0 }}
- {{cite journal | vauthors=Misiano P, Scott BB, Scheideler MA, Garnier M |title=PTH2 receptor-mediated inhibitory effect of parathyroid hormone and TIP39 on cell proliferation. |journal=Eur. J. Pharmacol. |volume=468 |issue= 3 |pages= 159–66 |year= 2004 |pmid= 12754053 |doi=10.1016/S0014-2999(03)01673-X }}
- {{cite journal |vauthors=Bisello A, Manen D, Pierroz DD, etal |title=Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization. |journal=Mol. Endocrinol. |volume=18 |issue= 6 |pages= 1486–98 |year= 2004 |pmid= 14988434 |doi= 10.1210/me.2003-0487 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
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