“TLK1”的意思、由来-开放百科全书

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]^[3]

References

1. ^{{cite journal | vauthors = Yamakawa A, Kameoka Y, Hashimoto K, Yoshitake Y, Nishikawa K, Tanihara K, Date T | title = cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal | journal = Gene | volume = 202 | issue = 1–2 | pages = 193–201 | date = Nov 1997 | pmid = 9427565 | pmc = | doi = 10.1016/S0378-1119(97)00495-2 }}
2. ^{{cite journal | vauthors = Groth A, Lukas J, Nigg EA, Silljé HH, Wernstedt C, Bartek J, Hansen K | title = Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint | journal = The EMBO Journal | volume = 22 | issue = 7 | pages = 1676–87 | date = Apr 2003 | pmid = 12660173 | pmc = 152895 | doi = 10.1093/emboj/cdg151 }}
3. ^¹{{cite web | title = Entrez Gene: TLK1 tousled-like kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9874| accessdate = }}
4. ^¹{{cite journal | vauthors = Silljé HH, Nigg EA | title = Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases | journal = Current Biology | volume = 11 | issue = 13 | pages = 1068–73 | date = Jul 2001 | pmid = 11470414 | doi = 10.1016/S0960-9822(01)00298-6 }}
5. ^{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
6. ^{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
7. ^{{cite journal | vauthors = Silljé HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA | title = Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication | journal = The EMBO Journal | volume = 18 | issue = 20 | pages = 5691–702 | date = Oct 1999 | pmid = 10523312 | pmc = 1171636 | doi = 10.1093/emboj/18.20.5691 }}

Further reading

{{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = Jun 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}

{{cite journal | vauthors = Schultz SJ, Nigg EA | title = Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans | journal = Cell Growth & Differentiation | volume = 4 | issue = 10 | pages = 821–30 | date = Oct 1993 | pmid = 8274451 | doi = }}

{{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 4 | pages = 167–74, 199–210 | date = Aug 1995 | pmid = 8590280 | doi = 10.1093/dnares/2.4.167 }}

{{cite journal | vauthors = Silljé HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA | title = Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication | journal = The EMBO Journal | volume = 18 | issue = 20 | pages = 5691–702 | date = Oct 1999 | pmid = 10523312 | pmc = 1171636 | doi = 10.1093/emboj/18.20.5691 }}

{{cite journal | vauthors = Cabaniols JP, Ravichandran V, Roche PA | title = Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly | journal = Molecular Biology of the Cell | volume = 10 | issue = 12 | pages = 4033–41 | date = Dec 1999 | pmid = 10588641 | pmc = 25741 | doi = 10.1091/mbc.10.12.4033 }}

{{cite journal | vauthors = Li Y, DeFatta R, Anthony C, Sunavala G, De Benedetti A | title = A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed | journal = Oncogene | volume = 20 | issue = 6 | pages = 726–38 | date = Feb 2001 | pmid = 11314006 | doi = 10.1038/sj.onc.1204147 }}

{{cite journal | vauthors = Silljé HH, Nigg EA | title = Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases | journal = Current Biology | volume = 11 | issue = 13 | pages = 1068–73 | date = Jul 2001 | pmid = 11470414 | doi = 10.1016/S0960-9822(01)00298-6 }}

{{cite journal | vauthors = Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou BB, Nigg EA, Khanna K | title = Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1 | journal = Oncogene | volume = 22 | issue = 38 | pages = 5927–37 | date = Sep 2003 | pmid = 12955071 | doi = 10.1038/sj.onc.1206691 }}

{{cite journal | vauthors = Norton KS, McClusky D, Sen S, Yu H, Meschonat C, Debenedetti A, Li BD | title = TLK1B is elevated with eIF4E overexpression in breast cancer | journal = The Journal of Surgical Research | volume = 116 | issue = 1 | pages = 98–103 | date = Jan 2004 | pmid = 14732354 | doi = 10.1016/j.jss.2003.08.001 }}

{{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}

{{cite journal | vauthors = Kodym R, Henöckl C, Fürweger C | title = Identification of the human DEAD-box protein p68 as a substrate of Tlk1 | journal = Biochemical and Biophysical Research Communications | volume = 333 | issue = 2 | pages = 411–7 | date = Jul 2005 | pmid = 15950181 | doi = 10.1016/j.bbrc.2005.05.136 }}

{{cite journal | vauthors = Sunavala-Dossabhoy G, Balakrishnan SK, Sen S, Nuthalapaty S, De Benedetti A | title = The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks | journal = BMC Molecular Biology | volume = 6 | pages = 19 | year = 2006 | pmid = 16156902 | pmc = 1242231 | doi = 10.1186/1471-2199-6-19 }}

{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

{{cite journal | vauthors = Sen SP, De Benedetti A | title = TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1 | journal = BMC Molecular Biology | volume = 7 | pages = 37 | year = 2006 | pmid = 17054786 | pmc = 1626478 | doi = 10.1186/1471-2199-7-37 }}

Function

Interactions

References

Further reading