请输入您要查询的百科知识：

　

词条 TMEM242
释义

  1. Domain

  2. Associated Proteins

  3. Function

  4. Gene Neighborhood

  5. Homologs and Orthologs

  6. Paralogs

  7. Evolutionary Information

  8. References

  9. External links

  10. Further reading

{{Infobox_gene}}Transmembrane protein 242 (TMEM242) is a protein that in humans is encoded by the TMEM242 gene.[1] The tmem242 gene is located on chromosome 6, on the long arm, in band 2 section 5.3. This protein is also commonly called C6orf35, BM033, and UPF0463 Transmembrane Protein C6orf35. The tmem242 gene is 35,238 base pairs long, and the protein is 141 amino acids in length. The tmem242 gene contains 4 exons[2]. The function of this protein is not well understood by the scientific community. This protein contains a DUF1358 domain (Domain of Unknown Function 1358).[3]

Domain

The TMEM242 protein has a conserved domain of unknown function pfam 07096, DUF 1358., which covers the first 121 aa of the protein. This domain is conserved in eukaryotes.

Associated Proteins

Several predicted interacting proteins and functional sites on the protein have been identified. One of the predicted interacting protein is MAP2K1IP1, which is a scaffold protein.[4] This protein is known to be involved in the MAP Kinase pathway. The MAP Kinase pathway is associated with the Alzheimer's pathway through a protein called Tau or MAPT. Excessive phosphorylation of this protein leads to aggregation of neurons which can cause Alzheimer's disease.

Function

The tmem242 protein is highly expressed in many tissues, but the most highly expressed in the brain, heart, adrenal, and thyroid [5].

Gene Neighborhood

Homologs and Orthologs

There are homologs and orthologs of the tmem242 protein in a variety of species. The species have diverged as far back as 794 million years ago[6]. The following species have been found as having orthologs to the tmem242 protein in their genome[7]:

  • Macaca fascicularis
  • Meriones unguicalutas
  • Rattus norvegicus
  • Sus scrofa
  • Ovis aries
  • Bubalus bubalis
  • Loxodonta africana
  • Vombatus ursinus
  • Python bivittatus
  • Corapipo alter
  • Notechis scutatu
  • Cuculus canorus
  • Xenopus tropicalis
  • Rhincodon typus
  • Acanthaster planci
  • Drosophila willistoni
  • Frankliniella occidentalis
  • Onthophagus taurus
  • Harpegnathos saltator
  • Orchesella cinctaB

Paralogs

The tmem242 protein has four paralogs in H. sapiens.[7] The full list is given below.

  • HSPC287
  • BM033
  • C6org35 Isoform CRA_a
  • hCG1820764

Evolutionary Information


References

1. ^{{cite web | title = Entrez Gene: chromosome 6 open reading frame 35| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=729515| accessdate = }}
2. ^{{Cite web|url=https://www.ncbi.nlm.nih.gov/protein/NP_060922|title=transmembrane protein 242 [Homo sapiens] - Protein - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2019-02-26}}
3. ^{{cite web| url =http://pfam.sanger.ac.uk/family?acc=PF07096| title =Pfam Family: DUF1358 (PF07096)| date =| format =| website =| publisher =Pfam| pages =| language =| archiveurl =https://web.archive.org/web/20120801215101/http://pfam.sanger.ac.uk/family?acc%3DPF07096| archivedate =2012-08-01| quote =| dead-url =yes| accessdate =}}
4. ^C6orf35 protein (Homo sapiens) - STRING interaction network
5. ^{{Cite web|url=https://www.ncbi.nlm.nih.gov/gene/729515|title=TMEM242 transmembrane protein 242 [Homo sapiens (human)] - Gene - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2019-02-26}}
6. ^{{Cite web|url=http://timetree.org/|title=TimeTree :: The Timescale of Life|website=timetree.org|access-date=2019-03-04}}
7. ^1 {{Cite web|url=https://blast.ncbi.nlm.nih.gov/Blast.cgi?PROGRAM=blastp&PAGE_TYPE=BlastSearch&LINK_LOC=blasthome|title=Protein BLAST: search protein databases using a protein query|website=blast.ncbi.nlm.nih.gov|access-date=2019-03-04}}

External links

  • {{UCSC gene info|TMEM242}}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1996 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |display-authors=etal}}
  • {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |pmc=1356129 |doi= 10.1101/gr.4039406 |display-authors=etal}}
  • {{cite journal |vauthors=Venter JC, Adams MD, Myers EW |title=The sequence of the human genome |journal=Science |volume=291 |issue= 5507 |pages= 1304–51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 |display-authors=etal}}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
{{refend}}{{gene-6-stub}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/28 19:27:12