| 词条 | TMUB2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| 释义 |
| section_title = | summary_text = }} GeneTMUB2 maps on the human chromosome 17, at locus 17q21.31.[3] TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right.[4] TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.[5] ExpressionTMUB2 is likely ubiquitously expressed throughout the human body.[6] It has a high expression level that is 2.9 times higher than other human genes.[7][8] ProteinThe TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions.[9] These will likely vary in orthologs. HomologyParalogsTMUB1 is the only paralog of TMUB2.[10][11] These proteins share a 38% identity and 51% similarity.[13] OrthologsThe table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.[12]
Protein InteractionsIn humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2.[13][14][15][16] Other proposed interactions include BCL2L13 (BCL2-like 13),[17] SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein),[17] and UBQLN1 (Ubiquilin-1).[17][18][19] References1. ^{{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal Biochem | volume = 236 | issue = 1 | pages = 107–113 |date=June 1996 | pmid = 8619474 | pmc = | doi = 10.1006/abio.1996.0138 }} 2. ^{{cite journal |vauthors=Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res | volume = 7 | issue = 4 | pages = 353–8 |date=June 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353}} 3. ^1 {{cite web | title = Entrez Gene: TMUB2 transmembrane and ubiquitin-like domain containing 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79089| accessdate = }} 4. ^[https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg19&position=chr17%3A42259020-42275597&hgsid=426041715_ANNefi64afxuGVINquJ7rpTa6bqE UCSC Genome Browser: BLAT Search] 5. ^[https://www.ncbi.nlm.nih.gov/gene/79089 NCBI Gene: TMUB2] 6. ^[https://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.181391 EST Profile Viewer: Human] 7. ^[https://www.ncbi.nlm.nih.gov/ieb/research/acembly/av.cgi?db=human&term=TMUB2&submit=Go Aceview: TMUB2] 8. ^[https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS596:218419_s_at NCBI GEO Profiles] 9. ^SDSC Biology Workbench 2.0 10. ^[https://www.genecards.org/cgi-bin/carddisp.pl?gene=TMUB2&search=5705db1fe27bd6e1da46a810e7cd5bb2 GeneCards: TMUB2] 11. ^[https://www.ncbi.nlm.nih.gov/gene/83590 NCBI Gene: TMUB1] 12. ^1 NCBI BLAST: Basic Local Alignment Search Tool 13. ^{{cite journal |author1=Danielsen Jannie M R |author2=Sylvestersen Kathrine B |author3=Bekker-Jensen Simon |author4=Szklarczyk Damian |author5=Poulsen Jon W |author6=Horn Heiko |author7=Jensen Lars J |author8=Mailand Niels |author9=Nielsen Michael L | year = 2011 | title = Mass Spectrometric Analysis of Lysine Ubiquitylation Reveals Promiscuity at Site Level | url = | journal = Molecular & Cellular Proteomics | volume = 10 | issue = 3| page = M110.003590 | doi = 10.1074/mcp.M110.003590 | pmid=21139048 | pmc=3047152}} 14. ^{{cite journal |author1=Wagner S. A. |author2=Beli P. |author3=Weinert B. T. |author4=Nielsen M. L. |author5=Cox J. |author6=Mann M. |author7=Choudhary C. | year = 2011 | title = A Proteome-Wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles | url = | journal = Molecular & Cellular Proteomics | volume = 10| issue = 10| pages = M111.013284| doi = 10.1074/mcp.M111.013284 | pmid=21890473 | pmc=3205876}} 15. ^{{cite journal |author1=Kim Woong |author2=Bennett Eric J. |author3=Huttlin Edward L. |author4=Guo Ailan |author5=Li Jing |author6=Possemato Anthony |author7=Sowa Mathew E. | year = 2011 | title = Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome | url = | journal = Molecular Cell | volume = 44 | issue = 2| pages = 325–40 | doi = 10.1016/j.molcel.2011.08.025 |display-authors=etal | pmid=21906983 | pmc=3200427}} 16. ^{{cite journal |author1=Povlsen Lou K. |author2=Beli Petra |author3=Wagner Sebastian A. |author4=Poulsen Sara L. |author5=Sylvestersen Kathrine B. |author6=Poulsen Jon W. |author7=Nielsen Michael L. |author8=Bekker-Jensen Simon |author9=Mailand Niels |author10=Choudhary Chunaram | year = 2012 | title = Systems-Wide Analysis of Ubiquitylation Dynamics Reveals a Key Role for PAF15 Ubiquitylation in DNA-Damage Bypass | url = | journal = Nature Cell Biology | volume = 14| issue = 10| pages = 1089–1098| doi = 10.1038/ncb2579 | pmid=23000965}} 17. ^1 2 {{cite journal |vauthors=Rolland T, Taşan M, Charloteaux B | date = November 2014 | title = A proteome-scale map of the human interactome network | url = | journal = Cell | volume = 159 | issue = 5| pages = 1212–26 | doi = 10.1016/j.cell.2014.10.050 | pmid = 25416956 | pmc=4266588|display-authors=etal}} 18. ^STRING: Functional Protein Association Networks 19. ^BioGRID Database Further reading{{refbegin | 2}}
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