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词条 TNKS
释义

  1. Description[4]

  2. Protein interactions

  3. References

  4. Further reading

{{Infobox_gene}}Tankyrase-1 is an enzyme that in humans is encoded by the TNKS gene.[1][2][3]

Description[4]

Tankyrase-1 is a poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.[5]

Protein interactions

TNKS has been shown to interact with:

{{div col|colwidth=20em}}
  • FNBP1,[6]
  • MCL1,[7]
  • TERF1,[1][9][10][8][9] and
  • TNKS1BP1.[10][11]
{{Div col end}}

References

1. ^1 {{cite journal | vauthors = Smith S, Giriat I, Schmitt A, de Lange T | title = Tankyrase, a poly(ADP-ribose) polymerase at human telomeres | journal = Science | volume = 282 | issue = 5393 | pages = 1484–7 | date = Dec 1998 | pmid = 9822378 | pmc = | doi = 10.1126/science.282.5393.1484 | citeseerx = 10.1.1.466.9024 }}
2. ^{{cite journal | vauthors = Zhu L, Smith S, de Lange T, Seldin MF | title = Chromosomal mapping of the tankyrase gene in human and mouse | journal = Genomics | volume = 57 | issue = 2 | pages = 320–1 | date = May 1999 | pmid = 10198177 | pmc = | doi = 10.1006/geno.1999.5771 }}
3. ^{{Cite web| title = Entrez Gene: TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8658| accessdate = }}
4. ^{{Cite web | url=https://www.uniprot.org/uniprot/O95271 | title=TNKS - Poly [ADP-ribose] polymerase tankyrase-1 - Homo sapiens (Human) - TNKS gene & protein}}
5. ^{{cite journal | pmid = 10872471 | doi=10.1146/annurev.biochem.68.1.1015 | volume=68 | title=The 26S proteasome: a molecular machine designed for controlled proteolysis | year=1999 | journal=Annu. Rev. Biochem. | pages=1015–68 | vauthors=Voges D, Zwickl P, Baumeister W}}
6. ^{{cite journal | vauthors = Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A | title = The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance | journal = FEBS Lett. | volume = 554 | issue = 1–2 | pages = 10–6 | date = Nov 2003 | pmid = 14596906 | doi = 10.1016/s0014-5793(03)01063-9}}
7. ^{{cite journal | vauthors = Bae J, Donigian JR, Hsueh AJ | title = Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis | journal = J. Biol. Chem. | volume = 278 | issue = 7 | pages = 5195–204 | date = Feb 2003 | pmid = 12475993 | doi = 10.1074/jbc.M201988200 }}
8. ^{{cite journal | vauthors = Cook BD, Dynek JN, Chang W, Shostak G, Smith S | title = Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres | journal = Mol. Cell. Biol. | volume = 22 | issue = 1 | pages = 332–42 | date = Jan 2002 | pmid = 11739745 | pmc = 134233 | doi = 10.1128/mcb.22.1.332-342.2002}}
9. ^{{cite journal | vauthors = Sbodio JI, Lodish HF, Chi NW | title = Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase) | journal = Biochem. J. | volume = 361 | issue = Pt 3 | pages = 451–9 | date = Feb 2002 | pmid = 11802774 | pmc = 1222327 | doi = 10.1042/0264-6021:3610451}}
10. ^1 {{cite journal | vauthors = Seimiya H, Smith S | title = The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182) | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 14116–26 | date = Apr 2002 | pmid = 11854288 | doi = 10.1074/jbc.M112266200 }}
11. ^1 {{cite journal | vauthors = Sbodio JI, Chi NW | title = Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner | journal = J. Biol. Chem. | volume = 277 | issue = 35 | pages = 31887–92 | date = Aug 2002 | pmid = 12080061 | doi = 10.1074/jbc.M203916200 }}

Further reading

{{Refbegin| 2}}
  • {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
  • {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
  • {{cite journal | vauthors = Smith S, de Lange T | title = Cell cycle dependent localization of the telomeric PARP, tankyrase, to nuclear pore complexes and centrosomes | journal = J. Cell Sci. | volume = 112 | issue = 21 | pages = 3649–56 | year = 1999 | pmid = 10523501 | doi = }}
  • {{cite journal | vauthors = Chi NW, Lodish HF | title = Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles | journal = J. Biol. Chem. | volume = 275 | issue = 49 | pages = 38437–44 | year = 2001 | pmid = 10988299 | doi = 10.1074/jbc.M007635200 }}
  • {{cite journal | vauthors = Lyons RJ, Deane R, Lynch DK, Ye ZS, Sanderson GM, Eyre HJ, Sutherland GR, Daly RJ | title = Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14 | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 17172–80 | year = 2001 | pmid = 11278563 | doi = 10.1074/jbc.M009756200 }}
  • {{cite journal | vauthors = Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C | title = Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7 | journal = J. Biol. Chem. | volume = 276 | issue = 31 | pages = 29393–402 | year = 2001 | pmid = 11382755 | doi = 10.1074/jbc.M101778200 }}
  • {{cite journal | vauthors = Cook BD, Dynek JN, Chang W, Shostak G, Smith S | title = Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres | journal = Mol. Cell. Biol. | volume = 22 | issue = 1 | pages = 332–42 | year = 2002 | pmid = 11739745 | pmc = 134233 | doi = 10.1128/MCB.22.1.332-342.2002 }}
  • {{cite journal | vauthors = Sbodio JI, Lodish HF, Chi NW | title = Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase) | journal = Biochem. J. | volume = 361 | issue = Pt 3 | pages = 451–9 | year = 2002 | pmid = 11802774 | pmc = 1222327 | doi = 10.1042/0264-6021:3610451 }}
  • {{cite journal | vauthors = Seimiya H, Smith S | title = The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182) | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 14116–26 | year = 2002 | pmid = 11854288 | doi = 10.1074/jbc.M112266200 }}
  • {{cite journal | vauthors = Sbodio JI, Chi NW | title = Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner | journal = J. Biol. Chem. | volume = 277 | issue = 35 | pages = 31887–92 | year = 2002 | pmid = 12080061 | doi = 10.1074/jbc.M203916200 }}
  • {{cite journal | vauthors = Rippmann JF, Damm K, Schnapp A | title = Functional characterization of the poly(ADP-ribose) polymerase activity of tankyrase 1, a potential regulator of telomere length | journal = J. Mol. Biol. | volume = 323 | issue = 2 | pages = 217–24 | year = 2002 | pmid = 12381316 | doi = 10.1016/S0022-2836(02)00946-4 }}
  • {{cite journal | vauthors = Bae J, Donigian JR, Hsueh AJ | title = Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis | journal = J. Biol. Chem. | volume = 278 | issue = 7 | pages = 5195–204 | year = 2003 | pmid = 12475993 | doi = 10.1074/jbc.M201988200 }}
  • {{cite journal | vauthors = Loayza D, De Lange T | title = POT1 as a terminal transducer of TRF1 telomere length control | journal = Nature | volume = 423 | issue = 6943 | pages = 1013–8 | year = 2003 | pmid = 12768206 | doi = 10.1038/nature01688 }}
  • {{cite journal | vauthors = Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A | title = The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance | journal = FEBS Lett. | volume = 554 | issue = 1–2 | pages = 10–6 | year = 2003 | pmid = 14596906 | doi = 10.1016/S0014-5793(03)01063-9 }}
  • {{cite journal | vauthors = Seimiya H, Muramatsu Y, Smith S, Tsuruo T | title = Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation | journal = Mol. Cell. Biol. | volume = 24 | issue = 5 | pages = 1944–55 | year = 2004 | pmid = 14966275 | pmc = 350561 | doi = 10.1128/MCB.24.5.1944-1955.2004 }}
  • {{cite journal | vauthors = Dynek JN, Smith S | title = Resolution of sister telomere association is required for progression through mitosis | journal = Science | volume = 304 | issue = 5667 | pages = 97–100 | year = 2004 | pmid = 15064417 | doi = 10.1126/science.1094754 }}
  • {{cite journal | vauthors = Ye JZ, de Lange T | title = TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex | journal = Nat. Genet. | volume = 36 | issue = 6 | pages = 618–23 | year = 2004 | pmid = 15133513 | doi = 10.1038/ng1360 }}
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3 : Telomeres|Telomere-related genes|Aging-related enzymes
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